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The Essence of Analgesia and Analgesics

Buffered aspirin and oral salicylate

Publication ,  Chapter
Blitz, J
January 1, 2010

Generic Name: aspirin Trade/Proprietary Name: Bayer Aspirin™, Bufferin™, Ecotrin™, Empirin™, Anacin™ Drug Class: anti-inflammatory drug Manufacturers: Bayer Health Care, 100 Bayer Road, Pittsburgh, PA 15205; Bristol Myers-Squibb, 5 Research Pkwy, Wallingford, CT 06492-1996 Chemical Name: acetylsalicylic acid Chemical Structure: see Figure 60.1 Description Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that has analgesic and antipyretic properties. It can be used alone to treat minor to moderate acute and chronic pain as well as pain associated with cancer. It is also available as preparations combined with caffeine or with an opioid analgesic to treat moderate to severe acute and chronic pain. Aspirin can be buffered (with calcium carbonate, magnesium oxide, and magnesium carbonate), or enteric coated to decrease the risk of gastric side effects such as dyspepsia, gastritis, bleeding, and ulceration. Mechanism of action Aspirin works to decrease pain by inhibiting inflammation at the cellular level. Prostaglandins sensitize pain receptors in afferent nerve endings to histamine and bradykinin, which begin the sensation of pain. Like other NSAIDs, aspirin inhibits cyclooxygenase (COX): the enzyme responsible for converting arachidonic acid to prostaglandin. Aspirin nonspecifically inhibits both COX 1 and 2 by acetylating them. Aspirin is a more potent inhibitor of both prostaglandin synthesis and platelet aggregation than other salicylic acid derivatives .

Duke Scholars

DOI

ISBN

9780521144506

Publication Date

January 1, 2010

Start / End Page

252 / 255
 

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Blitz, J. (2010). Buffered aspirin and oral salicylate. In The Essence of Analgesia and Analgesics (pp. 252–255). https://doi.org/10.1017/CBO9780511841378.060
Blitz, J. “Buffered aspirin and oral salicylate.” In The Essence of Analgesia and Analgesics, 252–55, 2010. https://doi.org/10.1017/CBO9780511841378.060.
Blitz J. Buffered aspirin and oral salicylate. In: The Essence of Analgesia and Analgesics. 2010. p. 252–5.
Blitz, J. “Buffered aspirin and oral salicylate.” The Essence of Analgesia and Analgesics, 2010, pp. 252–55. Scopus, doi:10.1017/CBO9780511841378.060.
Blitz J. Buffered aspirin and oral salicylate. The Essence of Analgesia and Analgesics. 2010. p. 252–255.
Journal cover image

DOI

ISBN

9780521144506

Publication Date

January 1, 2010

Start / End Page

252 / 255