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FIGURE 5 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma

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Chaudhary, R; Slebos, RJC; Noel, LC; Song, F; Poole, MI; Hoening, DS; Hernandez-Prera, JC; Conejo-Garcia, JR; Guevara-Patino, JA; Wang, X ...
May 22, 2023

<p>Cetuximab treatment benefits Hypoxia subgroup. <b>A,</b> Heatmap of gene expression data from pre- and post-cetuximab (CTX) treated patient samples. RNA expression data (GSE109756) was z-normalized, each row represents a single gene in the hypoxia-immune signature gene list, each column represents a patient sample. Hierarchical clustering was performed as detailed in Materials and Methods. Samples were reordered according to its molecular subgroup: Immune (blue), mixture (black), and Hypoxia (red) with pre-cetuximab treated samples labeled BC and post-cetuximab labeled OC. TIMEx scores for the Hypoxia gene signature among the 15 patients classified into the three subgroups (<b>B</b>) and GSEA comparing gene expression changes in the pre- and post-cetuximab data using CIBERSORT gene sets: higher in post-cetuximab (red) and higher in pre-ceuximab (blue) (<b>C</b>).</p>

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Publication Date

May 22, 2023
 

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Chaudhary, R., Slebos, R. J. C., Noel, L. C., Song, F., Poole, M. I., Hoening, D. S., … Chung, C. H. (2023). FIGURE 5 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma. https://doi.org/10.1158/2767-9764.23057218.v1
Chaudhary, Ritu, Robbert J. C. Slebos, Leenil C. Noel, Feifei Song, Maria I. Poole, Dirk S. Hoening, Juan C. Hernandez-Prera, et al. “FIGURE 5 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma,” May 22, 2023. https://doi.org/10.1158/2767-9764.23057218.v1.
Chaudhary, Ritu, et al. FIGURE 5 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma. 22 May 2023. Crossref, doi:10.1158/2767-9764.23057218.v1.
Chaudhary R, Slebos RJC, Noel LC, Song F, Poole MI, Hoening DS, Hernandez-Prera JC, Conejo-Garcia JR, Guevara-Patino JA, Wang X, Xie M, Tan AC, Chung CH. FIGURE 5 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma. 2023.

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Publication Date

May 22, 2023