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FIGURE 2 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma

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Chaudhary, R; Slebos, RJC; Noel, LC; Song, F; Poole, MI; Hoening, DS; Hernandez-Prera, JC; Conejo-Garcia, JR; Guevara-Patino, JA; Wang, X ...
May 22, 2023

<p>Hypoxia subgroup has immunosuppressive TME. Boxplots showing cell counts distribution of different immune markers CAIX<sup>+</sup> cells representing hypoxia marker (<b>A</b>), CD3<sup>+</sup> T cells (<b>B</b>), CD8<sup>+</sup> cytotoxic T cells (<b>C</b>), PCK<sup>+</sup> tumor cells expressing PD-L1 (<b>D</b>), HLA-DR<sup>+</sup> APCs (<b>E</b>), and CD8<sup>+</sup> T cells/FOXP3<sup>+</sup> Tregs (<b>F</b>), among the three subgroups in the TMA mIHC cohort (<i>n</i> = 90). Statistical analysis was performed by ANOVA test and followed by Tukey <i>post hoc</i> tests. <b>G,</b> Representative mIHC images showing that the average numbers of immune cells expressing CD3<sup>+</sup> T cells (green color), CD8<sup>+</sup> cytotoxic T cells (yellow color), CD69<sup>+</sup> activated T cells (red color), CD103<sup>+</sup> resident memory T cells (cyan color) within 20 μm of a PCK<sup>+</sup> cell (orange color) was statistically significantly lowest in the Hypoxia subgroup compared with the Mixture and Immune subgroups. Nuclei are shown in blue. Individual TMA core was considered as a region of interest (ROI). Bottom panel represents the zoom-in distance proximity and spatial distribution between a tumor cell and an immune cell within the TME.</p>

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Publication Date

May 22, 2023
 

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Chaudhary, R., Slebos, R. J. C., Noel, L. C., Song, F., Poole, M. I., Hoening, D. S., … Chung, C. H. (2023). FIGURE 2 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma. https://doi.org/10.1158/2767-9764.23057227.v1
Chaudhary, Ritu, Robbert J. C. Slebos, Leenil C. Noel, Feifei Song, Maria I. Poole, Dirk S. Hoening, Juan C. Hernandez-Prera, et al. “FIGURE 2 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma,” May 22, 2023. https://doi.org/10.1158/2767-9764.23057227.v1.
Chaudhary, Ritu, et al. FIGURE 2 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma. 22 May 2023. Crossref, doi:10.1158/2767-9764.23057227.v1.
Chaudhary R, Slebos RJC, Noel LC, Song F, Poole MI, Hoening DS, Hernandez-Prera JC, Conejo-Garcia JR, Guevara-Patino JA, Wang X, Xie M, Tan AC, Chung CH. FIGURE 2 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma. 2023.

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Publication Date

May 22, 2023