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Harnessing γδ T Cells against Human Gynecologic Cancers.

Publication ,  Journal Article
Conejo-Garcia, JR; Anadon, CM; Lopez-Bailon, LU; Chaurio, RA
Published in: Life (Basel)
February 29, 2024

Immuno-oncology has traditionally focused on conventional MHC-restricted αβ T cells. Yet, unconventional γδ T cells, which kill tumor cells in an MHC-unrestricted manner, display characteristics of effector activity and stemness without exhaustion and are nearly universally observed in human gynecologic malignancies, correlating with improved outcomes. These cells do not have a clear counterpart in mice but are also found in the healthy female reproductive tract. Interventions that modulate their in vivo activity, or cellular therapies utilizing γδ T cells as an allogeneic, "off-the-shelf" platform (e.g., for chimeric antigen receptor expression) hold significant potential against challenging tumors like ovarian cancer, which has been stubbornly resistant to the immune checkpoint inhibitors that change the landscape of other human tumors. Here, we discuss recent discoveries on the specific populations of γδ T cells that infiltrate human gynecologic cancers, their anti-tumor activity, and the prospect of redirecting their effector function against tumor cells to develop a new generation of immunotherapies that extends beyond the traditional αβ T cell-centric view of the field.

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Published In

Life (Basel)

DOI

ISSN

2075-1729

Publication Date

February 29, 2024

Volume

14

Issue

3

Location

Switzerland

Related Subject Headings

  • 4601 Applied computing
  • 3104 Evolutionary biology
  • 3101 Biochemistry and cell biology
 

Citation

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Conejo-Garcia, J. R., Anadon, C. M., Lopez-Bailon, L. U., & Chaurio, R. A. (2024). Harnessing γδ T Cells against Human Gynecologic Cancers. Life (Basel), 14(3). https://doi.org/10.3390/life14030325
Conejo-Garcia, Jose R., Carmen M. Anadon, Luis U. Lopez-Bailon, and Ricardo A. Chaurio. “Harnessing γδ T Cells against Human Gynecologic Cancers.Life (Basel) 14, no. 3 (February 29, 2024). https://doi.org/10.3390/life14030325.
Conejo-Garcia JR, Anadon CM, Lopez-Bailon LU, Chaurio RA. Harnessing γδ T Cells against Human Gynecologic Cancers. Life (Basel). 2024 Feb 29;14(3).
Conejo-Garcia, Jose R., et al. “Harnessing γδ T Cells against Human Gynecologic Cancers.Life (Basel), vol. 14, no. 3, Feb. 2024. Pubmed, doi:10.3390/life14030325.
Conejo-Garcia JR, Anadon CM, Lopez-Bailon LU, Chaurio RA. Harnessing γδ T Cells against Human Gynecologic Cancers. Life (Basel). 2024 Feb 29;14(3).

Published In

Life (Basel)

DOI

ISSN

2075-1729

Publication Date

February 29, 2024

Volume

14

Issue

3

Location

Switzerland

Related Subject Headings

  • 4601 Applied computing
  • 3104 Evolutionary biology
  • 3101 Biochemistry and cell biology