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Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors.

Publication ,  Journal Article
Hathaway, CA; Townsend, MK; Wang, T; Vinci, C; Jake-Schoffman, DE; Hecht, JL; Saeed-Vafa, D; Moran Segura, C; Nguyen, JV; Conejo-Garcia, JR ...
Published in: Cancer Epidemiol Biomarkers Prev
June 3, 2024

BACKGROUND: Cigarette smoke exposure has been linked to systemic immune dysfunction, including for B-cell and immunoglobulin (Ig) production, and poor outcomes in patients with ovarian cancer. No study has evaluated the impact of smoke exposure across the life-course on B-cell infiltration and Ig abundance in ovarian tumors. METHODS: We measured markers of B and plasma cells and Ig isotypes using multiplex immunofluorescence on 395 ovarian cancer tumors in the Nurses' Health Study (NHS)/NHSII. We conducted beta-binomial analyses evaluating odds ratios (OR) and 95% confidence intervals (CI) for positivity of immune markers by cigarette exposure among cases and Cox proportional hazards models to evaluate hazard ratios (HR) and 95% CI for developing tumors with low (

Duke Scholars

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

June 3, 2024

Volume

33

Issue

6

Start / End Page

796 / 803

Location

United States

Related Subject Headings

  • Ovarian Neoplasms
  • Middle Aged
  • Lymphocytes, Tumor-Infiltrating
  • Immunoglobulins
  • Humans
  • Female
  • Epidemiology
  • Cigarette Smoking
  • B-Lymphocytes
  • Aged
 

Citation

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Hathaway, C. A., Townsend, M. K., Wang, T., Vinci, C., Jake-Schoffman, D. E., Hecht, J. L., … Tworoger, S. S. (2024). Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors. Cancer Epidemiol Biomarkers Prev, 33(6), 796–803. https://doi.org/10.1158/1055-9965.EPI-23-1142
Hathaway, Cassandra A., Mary K. Townsend, Tianyi Wang, Christine Vinci, Danielle E. Jake-Schoffman, Jonathan L. Hecht, Daryoush Saeed-Vafa, et al. “Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors.Cancer Epidemiol Biomarkers Prev 33, no. 6 (June 3, 2024): 796–803. https://doi.org/10.1158/1055-9965.EPI-23-1142.
Hathaway CA, Townsend MK, Wang T, Vinci C, Jake-Schoffman DE, Hecht JL, et al. Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors. Cancer Epidemiol Biomarkers Prev. 2024 Jun 3;33(6):796–803.
Hathaway, Cassandra A., et al. “Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors.Cancer Epidemiol Biomarkers Prev, vol. 33, no. 6, June 2024, pp. 796–803. Pubmed, doi:10.1158/1055-9965.EPI-23-1142.
Hathaway CA, Townsend MK, Wang T, Vinci C, Jake-Schoffman DE, Hecht JL, Saeed-Vafa D, Moran Segura C, Nguyen JV, Conejo-Garcia JR, Fridley BL, Tworoger SS. Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors. Cancer Epidemiol Biomarkers Prev. 2024 Jun 3;33(6):796–803.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

June 3, 2024

Volume

33

Issue

6

Start / End Page

796 / 803

Location

United States

Related Subject Headings

  • Ovarian Neoplasms
  • Middle Aged
  • Lymphocytes, Tumor-Infiltrating
  • Immunoglobulins
  • Humans
  • Female
  • Epidemiology
  • Cigarette Smoking
  • B-Lymphocytes
  • Aged