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Data from Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors

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Hathaway, CA; Townsend, MK; Wang, T; Vinci, C; Jake-Schoffman, DE; Hecht, JL; Saeed-Vafa, D; Moran Segura, C; Nguyen, JV; Conejo-Garcia, JR ...
June 3, 2024

<div>AbstractBackground:<p>Cigarette smoke exposure has been linked to systemic immune dysfunction, including for B-cell and immunoglobulin (Ig) production, and poor outcomes in patients with ovarian cancer. No study has evaluated the impact of smoke exposure across the life-course on B-cell infiltration and Ig abundance in ovarian tumors.</p>Methods:<p>We measured markers of B and plasma cells and Ig isotypes using multiplex immunofluorescence on 395 ovarian cancer tumors in the Nurses’ Health Study (NHS)/NHSII. We conducted beta-binomial analyses evaluating odds ratios (OR) and 95% confidence intervals (CI) for positivity of immune markers by cigarette exposure among cases and Cox proportional hazards models to evaluate hazard ratios (HR) and 95% CI for developing tumors with low (Results:</p><p>There were no associations between smoke exposure and B-cell or IgM infiltration in ovarian tumors. Among cases, we observed higher odds of IgA<sup>+</sup> among ever smokers (OR, 1.54; 95% CI, 1.14–2.07) and ever smokers with no parental smoke exposure (OR, 2.03; 95% CI, 1.18–3.49) versus never smokers. Women with parental cigarette smoke exposure versus not had higher risk of developing ovarian cancer with low IgG<sup>+</sup> (HR, 1.51; 95% CI, 1.10–2.09), whereas ever versus never smokers had a lower risk (HR, 0.74; 95% CI, 0.56–0.99).</p>Conclusions:<p>Ever smoking was associated with increased odds of IgA in ovarian tumors.</p>Impact:<p>IgA has been associated with improved ovarian cancer outcomes, suggesting that although smoking is associated with poor outcomes in patients with ovarian cancer, it may lead to improved tumor immunogenicity.</p></div>

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June 3, 2024
 

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Hathaway, C. A., Townsend, M. K., Wang, T., Vinci, C., Jake-Schoffman, D. E., Hecht, J. L., … Tworoger, S. S. (2024). Data from Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors. https://doi.org/10.1158/1055-9965.c.7265906
Hathaway, Cassandra A., Mary K. Townsend, Tianyi Wang, Christine Vinci, Danielle E. Jake-Schoffman, Jonathan L. Hecht, Daryoush Saeed-Vafa, et al. “Data from Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors,” June 3, 2024. https://doi.org/10.1158/1055-9965.c.7265906.
Hathaway CA, Townsend MK, Wang T, Vinci C, Jake-Schoffman DE, Hecht JL, et al. Data from Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors. 2024.
Hathaway, Cassandra A., et al. Data from Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors. 3 June 2024. Crossref, doi:10.1158/1055-9965.c.7265906.
Hathaway CA, Townsend MK, Wang T, Vinci C, Jake-Schoffman DE, Hecht JL, Saeed-Vafa D, Moran Segura C, Nguyen JV, Conejo-Garcia JR, Fridley BL, Tworoger SS. Data from Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors. 2024.

DOI

Publication Date

June 3, 2024