Resistance to broadly neutralizing antibodies in perinatally infected infants from a Clade C HIV cohort in Mozambique.
Publication
, Journal Article
de Armas, LR; Tuyishime, M; Justement, JS; Jha, S; Dinh, V; Bone, B; Pahwa, R; Vaz, P; Lain, MG; Ferrari, G; Chun, T-W; Pahwa, S
Published in: AIDS
December 1, 2025
Antiretroviral therapy (ART) effectively controls HIV replication but adherence in infants and children remains a challenge. This study analyzed broadly neutralizing antibody (bNAb) resistance in viral isolates from perinatally infected infants from Mozambique. We found high intra-individual bNAb resistance heterogeneity, unrelated to viral burden, and evidence for early or preexisting resistance. These findings underscore the importance of individualized resistance screening and reinforce the need for accessible, adherence-supportive ART strategies in pediatric HIV.
Duke Scholars
Published In
AIDS
DOI
EISSN
1473-5571
Publication Date
December 1, 2025
Volume
39
Issue
15
Start / End Page
2321 / 2324
Location
England
Related Subject Headings
- Virology
- Viral Load
- Mozambique
- Male
- Infant, Newborn
- Infant
- Humans
- HIV-1
- HIV Infections
- HIV Antibodies
Citation
APA
Chicago
ICMJE
MLA
NLM
de Armas, L. R., Tuyishime, M., Justement, J. S., Jha, S., Dinh, V., Bone, B., … Pahwa, S. (2025). Resistance to broadly neutralizing antibodies in perinatally infected infants from a Clade C HIV cohort in Mozambique. AIDS, 39(15), 2321–2324. https://doi.org/10.1097/QAD.0000000000004318
Armas, Lesley R. de, Marina Tuyishime, J Shawn Justement, Shalini Jha, Vinh Dinh, Benjamin Bone, Rajendra Pahwa, et al. “Resistance to broadly neutralizing antibodies in perinatally infected infants from a Clade C HIV cohort in Mozambique.” AIDS 39, no. 15 (December 1, 2025): 2321–24. https://doi.org/10.1097/QAD.0000000000004318.
de Armas LR, Tuyishime M, Justement JS, Jha S, Dinh V, Bone B, et al. Resistance to broadly neutralizing antibodies in perinatally infected infants from a Clade C HIV cohort in Mozambique. AIDS. 2025 Dec 1;39(15):2321–4.
de Armas, Lesley R., et al. “Resistance to broadly neutralizing antibodies in perinatally infected infants from a Clade C HIV cohort in Mozambique.” AIDS, vol. 39, no. 15, Dec. 2025, pp. 2321–24. Pubmed, doi:10.1097/QAD.0000000000004318.
de Armas LR, Tuyishime M, Justement JS, Jha S, Dinh V, Bone B, Pahwa R, Vaz P, Lain MG, Ferrari G, Chun T-W, Pahwa S. Resistance to broadly neutralizing antibodies in perinatally infected infants from a Clade C HIV cohort in Mozambique. AIDS. 2025 Dec 1;39(15):2321–2324.
Published In
AIDS
DOI
EISSN
1473-5571
Publication Date
December 1, 2025
Volume
39
Issue
15
Start / End Page
2321 / 2324
Location
England
Related Subject Headings
- Virology
- Viral Load
- Mozambique
- Male
- Infant, Newborn
- Infant
- Humans
- HIV-1
- HIV Infections
- HIV Antibodies