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Age-disparate experiences and incidence of gender-based violence victimization of transgender women: findings from a cohort study in eastern and southern United States.

Journal articles  - Journal Article
Wirtz, AL; Humes, E; Poteat, TC; Althoff, KN; Mayer, KH; Cooney, EE; Stevenson, M; Pontes, C; Radix, AE; Wawrzyniak, AJ; Reisner, SL; LITE Study Group
Published in: Lancet Reg Health Am
January 2026

BACKGROUND: Gender-based violence (GBV) is a threat to health and human rights and experiences may vary with age. We estimated the incidence and correlates of GBV in transgender women in the United States. METHODS: From March 2018-August 2020, we enrolled a cohort (N = 1312) of transgender women without HIV in eastern and southern US. Participants were followed for 24-48 months via site-based and digital modes. We measured lifetime and recent (past 3 or 6 months) psychological, physical, and sexual GBV over follow-up. We calculated frequencies and incidence rates (IR) of each form of violence, stratified by age at enrollment (18-24 vs. ≥ 25 years). We used modified Poisson regression models to identify predictors of incident GBV and calculate adjusted relative risk (aRR) and 95% confidence intervals. FINDINGS: Participants were a mean age of 31years (standard deviation: 11) and 60% identified as White race (793/1312), 15% as Black (196/1312), and 19% as Hispanic/Latine (242/1312). At baseline, 88% (1140/1312) reported any lifetime GBV and 42% (546/1312) recent GBV. Psychological violence was most common (39% [507/1312] recent, 85% [1101/1312] lifetime), followed by physical (12% [151/1312] recent, 65% [843/1312] lifetime) and sexual (7% [94/1312] recent, 43% [557/1312] lifetime). Perpetrators were most frequently family members, partners, and strangers. Incidence of GBV was higher among young adults (IR = 119·4/100 person-years, 95% CI = 107·0-132·9) compared to adults (IR = 88·5/100 person-years, 95% CI = 81·7-95·6). Among young adults, online versus site-based participants had elevated GBV risk (aRR = 1·14, 95% CI = 1·03-1·26). Among adults, food insecurity (aRR:1·13, 95% CI:1·04-1·23), higher discrimination scores (aRR:1·01, 95% CI: 1·01-1·02), psychological distress (aRR:1·08, 95% CI:1·00-1·17), and drug use disorder symptoms (aRR:1·09, 95 CI:1·01-1·18) were associated with increased GBV risk. Other predictors were observed in age-specific models for incident psychological, physical, and sexual violence. INTERPRETATION: GBV is exceptionally high among US transgender women. Survivor services, protective policies, and interventions must explicitly address transgender women's needs, including age-specific GBV contexts. FUNDING: NIH.

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Published In

Lancet Reg Health Am

DOI

EISSN

2667-193X

Publication Date

January 2026

Volume

53

Start / End Page

101298

Location

England
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wirtz, A. L., Humes, E., Poteat, T. C., Althoff, K. N., Mayer, K. H., Cooney, E. E., … LITE Study Group. (2026). Age-disparate experiences and incidence of gender-based violence victimization of transgender women: findings from a cohort study in eastern and southern United States. Lancet Reg Health Am, 53, 101298. https://doi.org/10.1016/j.lana.2025.101298
Wirtz, Andrea L., Elizabeth Humes, Tonia C. Poteat, Keri N. Althoff, Kenneth H. Mayer, Erin E. Cooney, Meg Stevenson, et al. “Age-disparate experiences and incidence of gender-based violence victimization of transgender women: findings from a cohort study in eastern and southern United States.Lancet Reg Health Am 53 (January 2026): 101298. https://doi.org/10.1016/j.lana.2025.101298.
Wirtz AL, Humes E, Poteat TC, Althoff KN, Mayer KH, Cooney EE, et al. Age-disparate experiences and incidence of gender-based violence victimization of transgender women: findings from a cohort study in eastern and southern United States. Lancet Reg Health Am. 2026 Jan;53:101298.
Wirtz, Andrea L., et al. “Age-disparate experiences and incidence of gender-based violence victimization of transgender women: findings from a cohort study in eastern and southern United States.Lancet Reg Health Am, vol. 53, Jan. 2026, p. 101298. Pubmed, doi:10.1016/j.lana.2025.101298.
Wirtz AL, Humes E, Poteat TC, Althoff KN, Mayer KH, Cooney EE, Stevenson M, Pontes C, Radix AE, Wawrzyniak AJ, Reisner SL, LITE Study Group. Age-disparate experiences and incidence of gender-based violence victimization of transgender women: findings from a cohort study in eastern and southern United States. Lancet Reg Health Am. 2026 Jan;53:101298.

Published In

Lancet Reg Health Am

DOI

EISSN

2667-193X

Publication Date

January 2026

Volume

53

Start / End Page

101298

Location

England