Moderators of treatment response in late-life depression
Journal articles
- Review
Steffens, DC; Diniz, BS; Jain, N; Kluewer-D’Amico, J; Manning, KJ; Wang, L
Published in: Neuropsychopharmacology
January 1, 2026
As late-life depression is associated with a high degree of treatment resistance, understanding predictors of outcome may inform management. In this review, we examine a spectrum of factors that may moderate treatment response. These include clinical moderators related to depression presentation and history, social moderators, psychosocial stressors, personality, and cognitive factors. As there has been substantial research on biological predictors of response, we also include a review of neuroimaging moderators, including markers of accelerated brain aging, as well as other peripheral or central biomarkers of response.
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Published In
Neuropsychopharmacology
DOI
EISSN
1740-634X
ISSN
0893-133X
Publication Date
January 1, 2026
Related Subject Headings
- Psychiatry
- 5202 Biological psychology
- 3209 Neurosciences
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Steffens, D. C., Diniz, B. S., Jain, N., Kluewer-D’Amico, J., Manning, K. J., & Wang, L. (2026). Moderators of treatment response in late-life depression. Neuropsychopharmacology. https://doi.org/10.1038/s41386-026-02337-x
Steffens, D. C., B. S. Diniz, N. Jain, J. Kluewer-D’Amico, K. J. Manning, and L. Wang. “Moderators of treatment response in late-life depression.” Neuropsychopharmacology, January 1, 2026. https://doi.org/10.1038/s41386-026-02337-x.
Steffens DC, Diniz BS, Jain N, Kluewer-D’Amico J, Manning KJ, Wang L. Moderators of treatment response in late-life depression. Neuropsychopharmacology. 2026 Jan 1;
Steffens, D. C., et al. “Moderators of treatment response in late-life depression.” Neuropsychopharmacology, Jan. 2026. Scopus, doi:10.1038/s41386-026-02337-x.
Steffens DC, Diniz BS, Jain N, Kluewer-D’Amico J, Manning KJ, Wang L. Moderators of treatment response in late-life depression. Neuropsychopharmacology. 2026 Jan 1;
Published In
Neuropsychopharmacology
DOI
EISSN
1740-634X
ISSN
0893-133X
Publication Date
January 1, 2026
Related Subject Headings
- Psychiatry
- 5202 Biological psychology
- 3209 Neurosciences