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AI preference prediction beyond substituted judgement: enhancing best interest decision-making.

Publication ,  Journal Article
Weissglass, DE; Zhou, X; Min Htike, WY; Huang, Y; Li, Y; Mouzahim, M; Yu, K
Published in: Journal of medical ethics
April 2026

Tracking patient preferences is vital to medical decision-making, but evidence suggests that the standard method for tracking the preferences of incapacitated or incompetent patients (ie, surrogates) is inaccurate. Recent proposals suggest that artificial intelligence preference predictors (AIPPs) can improve preference tracking for these patients, but have faced significant objections. While many of these objections depend on unsettled empirical or technical assumptions, one prominent objection-that AIPPs rely inappropriately on impersonal information-seems to be an in-principle challenge to AIPPs. In this paper, we show that even granting an implausibly strong version of this objection, AIPPs may provide value to clinical decision-making. To show this, we develop suggestions that AIPPs may support best interest decision-making (BIDM) by improving the accuracy, consistency and speed of BIDM, and show that the prevalence of BIDM in the intensive care unit (ICU) grants this application of AIPPs significant moral and practical consequence. This not only clears a path to improve BIDM but also establishes a safe harbour-a relatively uncontroversial yet impactful space-in which proponents may develop AIPPs sufficently to resolve empirical and technical questions about their potential. We conclude by highlighting key questions for the application of AIPPs to BI determinations, setting an agenda for the deeper examination of a largely overlooked application of these tools.

Duke Scholars

Published In

Journal of medical ethics

DOI

EISSN

1473-4257

ISSN

0306-6800

Publication Date

April 2026

Start / End Page

jme-2026-111713

Related Subject Headings

  • Applied Ethics
  • 5001 Applied ethics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Weissglass, D. E., Zhou, X., Min Htike, W. Y., Huang, Y., Li, Y., Mouzahim, M., & Yu, K. (2026). AI preference prediction beyond substituted judgement: enhancing best interest decision-making. Journal of Medical Ethics, jme-2026-111713. https://doi.org/10.1136/jme-2026-111713
Weissglass, Daniel Elliot, Xinyu Zhou, Wai Yan Min Htike, Yifan Huang, Yujun Li, Marwa Mouzahim, and Kangpei Yu. “AI preference prediction beyond substituted judgement: enhancing best interest decision-making.Journal of Medical Ethics, April 2026, jme-2026-111713. https://doi.org/10.1136/jme-2026-111713.
Weissglass DE, Zhou X, Min Htike WY, Huang Y, Li Y, Mouzahim M, et al. AI preference prediction beyond substituted judgement: enhancing best interest decision-making. Journal of medical ethics. 2026 Apr;jme-2026-111713.
Weissglass, Daniel Elliot, et al. “AI preference prediction beyond substituted judgement: enhancing best interest decision-making.Journal of Medical Ethics, Apr. 2026, p. jme-2026-111713. Epmc, doi:10.1136/jme-2026-111713.
Weissglass DE, Zhou X, Min Htike WY, Huang Y, Li Y, Mouzahim M, Yu K. AI preference prediction beyond substituted judgement: enhancing best interest decision-making. Journal of medical ethics. 2026 Apr;jme-2026-111713.

Published In

Journal of medical ethics

DOI

EISSN

1473-4257

ISSN

0306-6800

Publication Date

April 2026

Start / End Page

jme-2026-111713

Related Subject Headings

  • Applied Ethics
  • 5001 Applied ethics