Advances in the Use of Cell-Based Therapies for Prevention of Bronchopulmonary Dysplasia.

Bronchopulmonary dysplasia (BPD) is a multifactorial disease characterized by disordered angiogenesis and disrupted alveolar development. Stem cell-based therapies, including extracellular vesicles, offer a transformative approach for BPD prevention and treatment. In preclinical studies, cell-based therapies promote lung repair, modulate immune responses, and replenish endogenous progenitor cells. This article critically evaluates the therapeutic potential of stem cell interventions for BPD, while also examining key barriers to clinical translation, including challenges in manufacturing, regulatory oversight, and standardization of cell-based products.

Duke Scholars

Author Kevin Williams Pediatrics, Neonatology