Digital heart failure management: Insights from the COPILOT study.

Suboptimal implementation of guideline-directed medical therapy (GDMT) remains a major problem in heart failure (HF) care. The Cooperative Program for Implementation of Optimal Therapy in Heart Failure (COPILOT-HF) trial evaluated an innovative remote strategy to optimize GDMT across the spectrum of HF, irrespective of left ventricular ejection fraction (LVEF). This pragmatic randomized study compared a pharmacist-led, navigator-assisted remote program against traditional provider notification and education. The results, recently presented at the American Heart Association 2025 Scientific Sessions, offer compelling insights into overcoming clinical inertia and improving HF management in the digital age. This mini review examines the trial’s key findings and their potential to reshape HF care delivery.

Duke Scholars

Author Stephen Greene Medicine, Cardiology