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Personalized feedback about immunity corrects risk misestimation and motivates vaccination.

Journal articles  - Journal Article
Sinclair, AH; Taylor, MK; Beckett, SJ; Chande, AT; Weitz, JS; Samanez-Larkin, GR
Published in: PNAS nexus
July 2026

Beliefs about immunity may have important consequences for health behaviors. For instance, people who overestimate their protection against a disease may neglect routine vaccinations, preventative measures, or diagnostic testing. Currently, few individuals are up-to-date on COVID-19 vaccines, leading to widespread gaps in protection. To address this challenge, we tested psychological interventions that targeted beliefs about immunity, providing personalized feedback about likely protection against COVID-19. In an online sample of participants (n = 882, stratified by age and gender), this intervention effectively changed immunity beliefs and increased vaccination intentions. Furthermore, the personalized intervention effectively realigned perceived risk (Cohen's d = 0.35), whereas an existing, widely used intervention produced by a national public health organization was ineffective (d = -0.03). The personalized intervention was particularly effective for older adults, who are at greater risk of experiencing severe illness if not sufficiently protected by vaccination. Two months later, belief changes endured, and self-reported vaccine uptake was 2-14× greater than the national rate in the United States during the same time period. Lastly, we scaled our intervention to an interactive public website and replicated our findings in an independent sample that was stratified to approximate the demographic makeup of the United States (n = 553). Overall, our psychological intervention changed immunity beliefs and motivated vaccination, of relevance for COVID-19, influenza, and future pandemic threats.

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Published In

PNAS nexus

DOI

EISSN

2752-6542

ISSN

2752-6542

Publication Date

July 2026

Volume

5

Issue

7

Start / End Page

pgag227
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sinclair, A. H., Taylor, M. K., Beckett, S. J., Chande, A. T., Weitz, J. S., & Samanez-Larkin, G. R. (2026). Personalized feedback about immunity corrects risk misestimation and motivates vaccination. PNAS Nexus, 5(7), pgag227. https://doi.org/10.1093/pnasnexus/pgag227
Sinclair, Alyssa H., Morgan K. Taylor, Stephen J. Beckett, Aroon T. Chande, Joshua S. Weitz, and Gregory R. Samanez-Larkin. “Personalized feedback about immunity corrects risk misestimation and motivates vaccination.PNAS Nexus 5, no. 7 (July 2026): pgag227. https://doi.org/10.1093/pnasnexus/pgag227.
Sinclair AH, Taylor MK, Beckett SJ, Chande AT, Weitz JS, Samanez-Larkin GR. Personalized feedback about immunity corrects risk misestimation and motivates vaccination. PNAS nexus. 2026 Jul;5(7):pgag227.
Sinclair, Alyssa H., et al. “Personalized feedback about immunity corrects risk misestimation and motivates vaccination.PNAS Nexus, vol. 5, no. 7, July 2026, p. pgag227. Epmc, doi:10.1093/pnasnexus/pgag227.
Sinclair AH, Taylor MK, Beckett SJ, Chande AT, Weitz JS, Samanez-Larkin GR. Personalized feedback about immunity corrects risk misestimation and motivates vaccination. PNAS nexus. 2026 Jul;5(7):pgag227.

Published In

PNAS nexus

DOI

EISSN

2752-6542

ISSN

2752-6542

Publication Date

July 2026

Volume

5

Issue

7

Start / End Page

pgag227