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Turning up the Heat with Therapeutic Epigenome Editing.

Other  - Journal Article
Zezulin, A; Musunuru, K
Published in: Cell stem cell
January 2018
Published version (DOI)

CRISPR-Cas9 has been touted for therapeutic genome editing, but limitations include inefficient correction of disease-causing mutations and off-target mutagenesis. In the latest issue of Cell, Liao et al. (2017) show that a modified version of CRISPR-Cas9 can target and activate key therapeutic genes in vivo without altering DNA sequence identity.

Duke Scholars

Alexandra Zezulin
Author Alexandra Zezulin  
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Published In

Cell stem cell

DOI

10.1016/j.stem.2017.12.013

EISSN

1875-9777

ISSN

1934-5909

Publication Date

January 2018

Volume

22

Issue

1

Start / End Page

10 / 11

Related Subject Headings

  • Mutagenesis
  • Gene Editing
  • Developmental Biology
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • CRISPR-Cas Systems
  • Base Sequence
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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MLA
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Zezulin, A., & Musunuru, K. (2018). Turning up the Heat with Therapeutic Epigenome Editing. Cell stem cell. https://doi.org/10.1016/j.stem.2017.12.013
Zezulin, Alexandra, and Kiran Musunuru. “Turning up the Heat with Therapeutic Epigenome Editing.” Cell Stem Cell, January 2018. https://doi.org/10.1016/j.stem.2017.12.013.
Zezulin A, Musunuru K. Turning up the Heat with Therapeutic Epigenome Editing. Vol. 22, Cell stem cell. 2018. p. 10–1.
Zezulin, Alexandra, and Kiran Musunuru. “Turning up the Heat with Therapeutic Epigenome Editing.” Cell Stem Cell, vol. 22, no. 1, Jan. 2018, pp. 10–11. Epmc, doi:10.1016/j.stem.2017.12.013.
Zezulin A, Musunuru K. Turning up the Heat with Therapeutic Epigenome Editing. Cell stem cell. 2018. p. 10–11.
Journal cover image

Published In

Cell stem cell

DOI

10.1016/j.stem.2017.12.013

EISSN

1875-9777

ISSN

1934-5909

Publication Date

January 2018

Volume

22

Issue

1

Start / End Page

10 / 11

Related Subject Headings

  • Mutagenesis
  • Gene Editing
  • Developmental Biology
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • CRISPR-Cas Systems
  • Base Sequence
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences