1262-P: Effect of Cardiovascular Risk Factor Control on Mortality in Older Adults—Findings from the Costa Rican Longevity and Healthy Aging Study

Introduction: The Costa Rican Longevity and Healthy Aging Study prospective cohort examined older adults' health status in Costa Rica. We investigated the influence of goal attainment on controlling cardiovascular risk factors (CVRFs): BMI, A1C, exercise, blood pressure, and smoking, along with their correlation with all-cause mortality. Methodology: Survival data from the initial 2005 visit to 2019 included 1943 participants. Categorization was based on meeting targets for five CVRFs. Hazard ratios for all-cause mortality were estimated, adjusting for age, sex, C-reactive protein category, and history of previous cardiovascular events. Results: The mean age for the cohort was 73.3 years, with 54.0% females. More than 2 hours of weekly exercise, controlled BMI, and A1C reduced all-cause mortality (aHR 0.77, 0.78, 0.72, respectively, p<0.001) (Figure 1a). Additionally, having 4 (aHR 0.50, p=0.035) or 5 (aHR 0.34, p=0.007) controlled CVRFs reduced overall mortality within the cohort. Conclusions: A controlled A1C and BMI and engaging in exercise correlated with reduced mortality in the Costa Rican elderly population. Additionally, aHRs for all-cause mortality decreased as more CVRFs were controlled, emphasizing the crucial role of managing these multiple factors in this population.

Duke Scholars

Author Gabriel Torrealba-Acosta Neurology, Neurocritical Care