2266-P: Multimorbidity Phenotypes in Diabetes and Their Association with All-Cause Mortality: A Latent Class Analysis in the UK Biobank

Introduction and Objective: Multimorbidity is common in diabetes and affects long-term survival. We aimed to identify multimorbidity phenotypes and their link to 10-year all-cause mortality. Methods: We applied latent class analysis to 28,043 adults with diabetes using 22 comorbidity indicators and identified 4 multimorbidity phenotypes. Multivariable-adjusted Cox models were fitted. Results: Mortality was 19.1 per 1,000 person-years. Compared with minimally comorbid diabetes, the aHR for mortality risk increased across clusters of multimorbidity: hypertension-predominant cardiometabolic (1.24, 95% CI 1.16-1.32), high inflammatory and psycho-metabolic burden (1.48, 95% CI 1.33-1.64), and cancer-cardiometabolic high-burden (1.97, 95% CI 1.80-2.15). Conclusion: LCA-derived phenotypes capture mortality risk beyond single-condition approaches in diabetes.

Duke Scholars

Author Gabriel Torrealba-Acosta Neurology, Neurocritical Care