2265-P: Multimorbidity Phenotypes in Diabetes and Their Association with 10-Year Dementia Risk: A Latent Class Analysis in the UK Biobank

Introduction and Objective: Multimorbidity is common in diabetes and may impact cognitive risk. We used latent class analysis to identify multimorbidity phenotypes and their association with incident dementia. Methods: We included 28,043 adults with diabetes. Twenty-two comorbidity indicators were used to identify multimorbidity classes. We fitted Cox models adjusted for sociodemographic and clinical variables. Results: The incidence of dementia was 4.28 per 1,000 patients/year. Compared with minimally comorbid diabetes, both the inflammatory-psycho-metabolic and the cancer-cardiometabolic high-burden phenotypes showed increased dementia risk, with aHR of 1.69 (95% CI 1.36-2.09) and 1.92 (95% CI 1.59-2.30), respectively. Conclusion: Multimorbidity patterns identify high-risk dementia subgroups and may aid stratification beyond single-disease measures.

Duke Scholars

Author Gabriel Torrealba-Acosta Neurology, Neurocritical Care