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Supplementary Figure S3 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

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Strawser, CH; Chakraborty, B; Michaud, D; Chang, C-Y; Dent, S; Jain, V; Tolaney, SM; Weinhold, K; McAllister, SS; Miller, KE; Steadman, K ...
August 3, 2026

<p>Supplementary Fig. S3. A) UMAP visualization of G1/S CDKs, CDK4, CDK6, and CDK2. B) C) Heatmap depicting differential expression of CDK4/6 target genes and proliferation markers in each cluster grouped by response. Color indicates average log2FC where a positive value indicates the gene was more highly expressed at T2. * FDR £ 0.05. UMAP visualization of hormone receptor genes, ESR1, ESR2, GPER1, PGR and AR and ER target genes, GREB1 and TFF1 in lymphoid clusters split by timepoint.</p>

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August 3, 2026
 

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Strawser, C. H., Chakraborty, B., Michaud, D., Chang, C.-Y., Dent, S., Jain, V., … Sammons, S. (2026). Supplementary Figure S3 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy. https://doi.org/10.1158/1078-0432.33142992
Strawser, Corinne H., Binita Chakraborty, Daniel Michaud, Ching-Yi Chang, Susan Dent, Vaibhav Jain, Sara M. Tolaney, et al. “Supplementary Figure S3 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy,” August 3, 2026. https://doi.org/10.1158/1078-0432.33142992.
Strawser CH, Chakraborty B, Michaud D, Chang C-Y, Dent S, Jain V, Tolaney SM, Weinhold K, McAllister SS, Miller KE, Steadman K, Arvai S, Hocke E, Agrawal Y, Perou CM, Goel S, McDonnell DP, Guerriero JL, Sammons S. Supplementary Figure S3 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy. 2026.

DOI

Publication Date

August 3, 2026