Scholars@Duke publication: Supplementary Figure S4 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Supplementary Figure S4 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

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Strawser, CH; Chakraborty, B; Michaud, D; Chang, C-Y; Dent, S; Jain, V; Tolaney, SM; Weinhold, K; McAllister, SS; Miller, KE; Steadman, K ...

August 3, 2026

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<p>Supplementary Fig. S4. A) Box plot of IFNG expression at T1 and T2 for each T cell cluster grouped by response. Median expression is indicated by green line. Statistical significance determined by two-way ANOVA with post-hoc Tukey-HSD test. *p.adjust £ 0.05. B) Heatmap depicting gene set enrichment results identified from genes that were differentially expressed between T1 and T2 for each lymphoid cluster in each response group. Color indicates normalized enrichment score where a positive value indicates the pathway was more highly expressed at T2. * FDR £ 0.05.</p>

Duke Scholars

Author Binita Chakraborty

Author Kent James Weinhold Surgery, Surgical Sciences

Author Ching-yi Chang Pharmacology & Cancer Biology

Author Donald Patrick McDonnell Pharmacology & Cancer Biology

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DOI

10.1158/1078-0432.33142989

Publication Date

August 3, 2026

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Strawser, C. H., Chakraborty, B., Michaud, D., Chang, C.-Y., Dent, S., Jain, V., … Sammons, S. (2026). Supplementary Figure S4 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy. https://doi.org/10.1158/1078-0432.33142989

Strawser, Corinne H., Binita Chakraborty, Daniel Michaud, Ching-Yi Chang, Susan Dent, Vaibhav Jain, Sara M. Tolaney, et al. “Supplementary Figure S4 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy,” August 3, 2026. https://doi.org/10.1158/1078-0432.33142989.

Strawser CH, Chakraborty B, Michaud D, Chang C-Y, Dent S, Jain V, et al. Supplementary Figure S4 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy. 2026.

Strawser, Corinne H., et al. Supplementary Figure S4 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy. 3 Aug. 2026. Crossref, doi:10.1158/1078-0432.33142989.

Strawser CH, Chakraborty B, Michaud D, Chang C-Y, Dent S, Jain V, Tolaney SM, Weinhold K, McAllister SS, Miller KE, Steadman K, Arvai S, Hocke E, Agrawal Y, Perou CM, Goel S, McDonnell DP, Guerriero JL, Sammons S. Supplementary Figure S4 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy. 2026.

DOI

10.1158/1078-0432.33142989

Publication Date

August 3, 2026