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Effects of antipsychotic withdrawal in elderly nursing home residents.

Publication ,  Journal Article
Thapa, PB; Meador, KG; Gideon, P; Fought, RL; Ray, WA
Published in: J Am Geriatr Soc
March 1994

OBJECTIVE: To study the effects of antipsychotic withdrawal in elderly nursing home residents. DESIGN: Longitudinal prospective study. SETTING: 12 community nursing homes that participated in a randomized controlled trial of an educational program designed to reduce antipsychotic use. SUBJECTS: 271 residents receiving antipsychotics at baseline and remaining in the home for approximately 6 months thereafter. These were placed into two groups: those with continued use of antipsychotics at follow-up (n = 207) and those with drug discontinued (n = 64). MEASUREMENTS: Change between baseline and follow-up for several standard measurements. These included behavior problems, as reported by both regular care providers (Nursing Home Behavior Problem Scale) or a blinded study rater (items from the Brief Psychiatric Rating Scale), observer-rated psychiatric symptoms (subset of the Brief Psychiatric Rating Scale), and other standard tests of function (Activities of Daily Living, Mini-Mental State Examination, Geriatric Depression Scale, and Abnormal Involuntary Movements Scale). RESULTS: The frequency of behavior problems did not increase in residents with antipsychotics discontinued. For these residents, observer-rated psychiatric symptoms decreased by 21% (P = 0.003), which resulted from a 27% decrease in adverse affective symptoms (P = 0.0002). Residents with drug discontinued had no deterioration in any of the measures of function. CONCLUSION: In this sample, nursing home residents whose antipsychotics were discontinued had significantly improved affect and no discernable adverse effects.

Duke Scholars

Published In

J Am Geriatr Soc

DOI

ISSN

0002-8614

Publication Date

March 1994

Volume

42

Issue

3

Start / End Page

280 / 286

Location

United States

Related Subject Headings

  • Prospective Studies
  • Nursing Homes
  • Male
  • Longitudinal Studies
  • Humans
  • Geriatrics
  • Female
  • Dementia
  • Cognition
  • Behavior
 

Citation

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Thapa, P. B., Meador, K. G., Gideon, P., Fought, R. L., & Ray, W. A. (1994). Effects of antipsychotic withdrawal in elderly nursing home residents. J Am Geriatr Soc, 42(3), 280–286. https://doi.org/10.1111/j.1532-5415.1994.tb01752.x
Thapa, P. B., K. G. Meador, P. Gideon, R. L. Fought, and W. A. Ray. “Effects of antipsychotic withdrawal in elderly nursing home residents.J Am Geriatr Soc 42, no. 3 (March 1994): 280–86. https://doi.org/10.1111/j.1532-5415.1994.tb01752.x.
Thapa PB, Meador KG, Gideon P, Fought RL, Ray WA. Effects of antipsychotic withdrawal in elderly nursing home residents. J Am Geriatr Soc. 1994 Mar;42(3):280–6.
Thapa, P. B., et al. “Effects of antipsychotic withdrawal in elderly nursing home residents.J Am Geriatr Soc, vol. 42, no. 3, Mar. 1994, pp. 280–86. Pubmed, doi:10.1111/j.1532-5415.1994.tb01752.x.
Thapa PB, Meador KG, Gideon P, Fought RL, Ray WA. Effects of antipsychotic withdrawal in elderly nursing home residents. J Am Geriatr Soc. 1994 Mar;42(3):280–286.
Journal cover image

Published In

J Am Geriatr Soc

DOI

ISSN

0002-8614

Publication Date

March 1994

Volume

42

Issue

3

Start / End Page

280 / 286

Location

United States

Related Subject Headings

  • Prospective Studies
  • Nursing Homes
  • Male
  • Longitudinal Studies
  • Humans
  • Geriatrics
  • Female
  • Dementia
  • Cognition
  • Behavior