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Right ventricular failure--insights provided by a new model of chronic pulmonary hypertension.

Publication ,  Journal Article
Chen, EP; Bittner, HB; Davis, RD; Van Trigt, P
Published in: Transplantation
January 27, 1997

This study was designed to examine the effects of both nitric oxide and milrinone on pulmonary hemodynamics and right ventricular function using a newly established model of monocrotaline pyrrole-induced chronic pulmonary hypertension. Sixteen mongrel dogs (23-25 kg) were used. All animals underwent percutanous pulmonary artery catheterization to measure right heart hemodynamics prior to and 8 weeks after a right atrial injection of either monocrotaline pyrrole (MCTP, n=8) or placebo (CTL, n=8). Eight weeks postinjection, all hearts were instrumented with a pulmonary artery flow probe and intracavitary micromanometers. Data were collected at baseline as well as following both nitric oxide and milrinone administration. There was no significant difference in the baseline hemodynamic measurements between the two groups. Eight weeks postinjection, significant increases in the pulmonary artery pressure and pulmonary vascular resistance were observed in MCTP compared with CTL. Both nitric oxide and milrinone resulted in significant improvements in pulmonary vascular resistance, pulmonary blood flow, and right ventricular contractility. In addition, nitric oxide caused a significant improvement in pulmonary artery pressure and transpulmonary efficiency, while milrinone led to a significant increase in right ventricular hydraulic power. This study demonstrates the well-known clinical effects of nitric oxide and milrinone in improving pulmonary hypertension, which were also associated with an increase in pulmonary blood flow, transpulmonary efficiency, and right ventricular hydraulic power in the setting of monocrotaline pyrrole-induced chronic pulmonary hypertension.

Duke Scholars

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

January 27, 1997

Volume

63

Issue

2

Start / End Page

209 / 216

Location

United States

Related Subject Headings

  • Ventricular Function, Right
  • Ventricular Dysfunction, Right
  • Vasodilator Agents
  • Vascular Resistance
  • Surgery
  • Pyridones
  • Pulmonary Artery
  • Nitric Oxide
  • Monocrotaline
  • Milrinone
 

Citation

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Chen, E. P., Bittner, H. B., Davis, R. D., & Van Trigt, P. (1997). Right ventricular failure--insights provided by a new model of chronic pulmonary hypertension. Transplantation, 63(2), 209–216. https://doi.org/10.1097/00007890-199701270-00006
Chen, E. P., H. B. Bittner, R. D. Davis, and P. Van Trigt. “Right ventricular failure--insights provided by a new model of chronic pulmonary hypertension.Transplantation 63, no. 2 (January 27, 1997): 209–16. https://doi.org/10.1097/00007890-199701270-00006.
Chen EP, Bittner HB, Davis RD, Van Trigt P. Right ventricular failure--insights provided by a new model of chronic pulmonary hypertension. Transplantation. 1997 Jan 27;63(2):209–16.
Chen, E. P., et al. “Right ventricular failure--insights provided by a new model of chronic pulmonary hypertension.Transplantation, vol. 63, no. 2, Jan. 1997, pp. 209–16. Pubmed, doi:10.1097/00007890-199701270-00006.
Chen EP, Bittner HB, Davis RD, Van Trigt P. Right ventricular failure--insights provided by a new model of chronic pulmonary hypertension. Transplantation. 1997 Jan 27;63(2):209–216.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

January 27, 1997

Volume

63

Issue

2

Start / End Page

209 / 216

Location

United States

Related Subject Headings

  • Ventricular Function, Right
  • Ventricular Dysfunction, Right
  • Vasodilator Agents
  • Vascular Resistance
  • Surgery
  • Pyridones
  • Pulmonary Artery
  • Nitric Oxide
  • Monocrotaline
  • Milrinone