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The effects of N(omega)-propyl-L-arginine on reperfusion injury of skeletal muscle.

Publication ,  Journal Article
Gowda, C; Toomayan, GA; Qi, W-N; Chen, L-E; Cai, Y; Allen, DM; Seaber, AV; Urbaniak, JR
Published in: Nitric Oxide
August 2004

N(omega)-Propyl-L-arginine (NPA) is reported to be a highly selective inhibitor of neuronal nitric oxide synthase (nNOS). This in vivo study observed its role in ischemia/reperfusion (I/R) injury in rat skeletal muscle. Our results showed that NPA infusion significantly increased vessel diameters and blood flow in reperfused cremaster muscle, and slightly increased contractile function in reperfused extensor digitorum longus (EDL) muscle. In addition, NPA treatment slightly increased I/R-mediated downregulation of nNOS and eNOS mRNA and protein levels. Although NPA showed a beneficial role in I/R injury, our in vivo data do not support NPA as a selective nNOS inhibitor. Also, our data do not provide any insight into the mechanism of NPA. Thus, the in vivo mechanism of action of NPA needs to be further identified, and the role of nNOS in skeletal muscle I/R still remains to be determined.

Duke Scholars

Published In

Nitric Oxide

DOI

ISSN

1089-8603

Publication Date

August 2004

Volume

11

Issue

1

Start / End Page

17 / 24

Location

United States

Related Subject Headings

  • Reperfusion Injury
  • Rats, Sprague-Dawley
  • Rats
  • Nitric Oxide Synthase Type III
  • Nitric Oxide Synthase Type I
  • Nitric Oxide Synthase
  • Nerve Tissue Proteins
  • Muscle, Skeletal
  • Muscle Contraction
  • Microcirculation
 

Citation

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ICMJE
MLA
NLM
Gowda, C., Toomayan, G. A., Qi, W.-N., Chen, L.-E., Cai, Y., Allen, D. M., … Urbaniak, J. R. (2004). The effects of N(omega)-propyl-L-arginine on reperfusion injury of skeletal muscle. Nitric Oxide, 11(1), 17–24. https://doi.org/10.1016/j.niox.2004.07.007
Gowda, Charan, Glen A. Toomayan, Wen-Ning Qi, Long-En Chen, Yongting Cai, Diane M. Allen, Anthony V. Seaber, and James R. Urbaniak. “The effects of N(omega)-propyl-L-arginine on reperfusion injury of skeletal muscle.Nitric Oxide 11, no. 1 (August 2004): 17–24. https://doi.org/10.1016/j.niox.2004.07.007.
Gowda C, Toomayan GA, Qi W-N, Chen L-E, Cai Y, Allen DM, et al. The effects of N(omega)-propyl-L-arginine on reperfusion injury of skeletal muscle. Nitric Oxide. 2004 Aug;11(1):17–24.
Gowda, Charan, et al. “The effects of N(omega)-propyl-L-arginine on reperfusion injury of skeletal muscle.Nitric Oxide, vol. 11, no. 1, Aug. 2004, pp. 17–24. Pubmed, doi:10.1016/j.niox.2004.07.007.
Gowda C, Toomayan GA, Qi W-N, Chen L-E, Cai Y, Allen DM, Seaber AV, Urbaniak JR. The effects of N(omega)-propyl-L-arginine on reperfusion injury of skeletal muscle. Nitric Oxide. 2004 Aug;11(1):17–24.
Journal cover image

Published In

Nitric Oxide

DOI

ISSN

1089-8603

Publication Date

August 2004

Volume

11

Issue

1

Start / End Page

17 / 24

Location

United States

Related Subject Headings

  • Reperfusion Injury
  • Rats, Sprague-Dawley
  • Rats
  • Nitric Oxide Synthase Type III
  • Nitric Oxide Synthase Type I
  • Nitric Oxide Synthase
  • Nerve Tissue Proteins
  • Muscle, Skeletal
  • Muscle Contraction
  • Microcirculation