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Measurement of cellular proliferation within the vitreous during experimental proliferative vitreoretinopathy.

Publication ,  Journal Article
Yang, CM; Olsen, KR; Hernandez, E; Cousins, SW
Published in: Graefes Arch Clin Exp Ophthalmol
1992

Cellular proliferation is an important component in the pathogenesis of complex retinal detachments caused by proliferative vitreoretinopathy (PVR). We used flow cytometry to measure the proliferation of cells recovered from the vitreous cavity in an experimental model of tractional retinal detachment induced by homologous fibroblast injection. Two distinct populations of cells were detected. One population comprised smaller, dense cells representing mostly leukocytes. A second population of larger cells contained not only the injected fibroblasts but also high concentrations of host-derived cells with significant proliferative activity, whose number increased for 3 days following injection. Flow cytometry was useful for analysis of the recovered cells for concentration, morphologic features and proliferation. This technique may be applicable in the identification of patients at high risk for the development of PVR.

Duke Scholars

Published In

Graefes Arch Clin Exp Ophthalmol

DOI

ISSN

0721-832X

Publication Date

1992

Volume

230

Issue

1

Start / End Page

66 / 71

Location

Germany

Related Subject Headings

  • Vitreous Body
  • Retinal Diseases
  • Retinal Detachment
  • Rabbits
  • Ophthalmology & Optometry
  • Leukocytes
  • Flow Cytometry
  • Fibroblasts
  • Eye Diseases
  • Disease Models, Animal
 

Citation

APA
Chicago
ICMJE
MLA
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Yang, C. M., Olsen, K. R., Hernandez, E., & Cousins, S. W. (1992). Measurement of cellular proliferation within the vitreous during experimental proliferative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol, 230(1), 66–71. https://doi.org/10.1007/BF00166765
Yang, C. M., K. R. Olsen, E. Hernandez, and S. W. Cousins. “Measurement of cellular proliferation within the vitreous during experimental proliferative vitreoretinopathy.Graefes Arch Clin Exp Ophthalmol 230, no. 1 (1992): 66–71. https://doi.org/10.1007/BF00166765.
Yang CM, Olsen KR, Hernandez E, Cousins SW. Measurement of cellular proliferation within the vitreous during experimental proliferative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol. 1992;230(1):66–71.
Yang, C. M., et al. “Measurement of cellular proliferation within the vitreous during experimental proliferative vitreoretinopathy.Graefes Arch Clin Exp Ophthalmol, vol. 230, no. 1, 1992, pp. 66–71. Pubmed, doi:10.1007/BF00166765.
Yang CM, Olsen KR, Hernandez E, Cousins SW. Measurement of cellular proliferation within the vitreous during experimental proliferative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol. 1992;230(1):66–71.
Journal cover image

Published In

Graefes Arch Clin Exp Ophthalmol

DOI

ISSN

0721-832X

Publication Date

1992

Volume

230

Issue

1

Start / End Page

66 / 71

Location

Germany

Related Subject Headings

  • Vitreous Body
  • Retinal Diseases
  • Retinal Detachment
  • Rabbits
  • Ophthalmology & Optometry
  • Leukocytes
  • Flow Cytometry
  • Fibroblasts
  • Eye Diseases
  • Disease Models, Animal