The mechanism of action of angiostatin: can you teach an old dog new tricks?
Publication
, Journal Article
Moser, TL; Stack, MS; Wahl, ML; Pizzo, SV
Published in: Thromb Haemost
March 2002
What is angiostatin? In 1994, Folkman and colleagues published a landmark paper describing anti-tumor effects in mice with a purified fragment of plasminogen they named angiostatin (1). Although many papers have been published describing activities of cryptic polypeptides derived from plasminogen fragments, this was the first report which associated plasminogen kringles 1-4 as a suppressor of metastasis development. This review will describe what is known about the mechanism of action of angiostatin from the current literature.
Duke Scholars
Published In
Thromb Haemost
ISSN
0340-6245
Publication Date
March 2002
Volume
87
Issue
3
Start / End Page
394 / 401
Location
Germany
Related Subject Headings
- Plasminogen
- Peptide Fragments
- Mitochondrial Proton-Translocating ATPases
- Humans
- Cardiovascular System & Hematology
- Binding Sites
- Antineoplastic Agents
- Animals
- Angiostatins
- Angiogenesis Inhibitors
Citation
APA
Chicago
ICMJE
MLA
NLM
Moser, T. L., Stack, M. S., Wahl, M. L., & Pizzo, S. V. (2002). The mechanism of action of angiostatin: can you teach an old dog new tricks? Thromb Haemost, 87(3), 394–401.
Moser, Tammy L., M Sharon Stack, Miriam L. Wahl, and Salvatore V. Pizzo. “The mechanism of action of angiostatin: can you teach an old dog new tricks?” Thromb Haemost 87, no. 3 (March 2002): 394–401.
Moser TL, Stack MS, Wahl ML, Pizzo SV. The mechanism of action of angiostatin: can you teach an old dog new tricks? Thromb Haemost. 2002 Mar;87(3):394–401.
Moser, Tammy L., et al. “The mechanism of action of angiostatin: can you teach an old dog new tricks?” Thromb Haemost, vol. 87, no. 3, Mar. 2002, pp. 394–401.
Moser TL, Stack MS, Wahl ML, Pizzo SV. The mechanism of action of angiostatin: can you teach an old dog new tricks? Thromb Haemost. 2002 Mar;87(3):394–401.
Published In
Thromb Haemost
ISSN
0340-6245
Publication Date
March 2002
Volume
87
Issue
3
Start / End Page
394 / 401
Location
Germany
Related Subject Headings
- Plasminogen
- Peptide Fragments
- Mitochondrial Proton-Translocating ATPases
- Humans
- Cardiovascular System & Hematology
- Binding Sites
- Antineoplastic Agents
- Animals
- Angiostatins
- Angiogenesis Inhibitors