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Reduced thrombus burden with abciximab delivered locally before percutaneous intervention in saphenous vein grafts.

Publication ,  Journal Article
Barsness, GW; Buller, C; Ohman, EM; Schechter, E; Pucillo, A; Taylor, MA; Miller, MJ; Reiner, JS; Churchill, D; Chandler, AB; Gonzalez, M ...
Published in: Am Heart J
May 2000

BACKGROUND: Existing thrombus can complicate percutaneous saphenous vein graft (SVG) intervention. Local delivery of thrombolytics has been used to reduce the thrombus burden often associated with these interventions. We sought to determine whether local delivery of a platelet glycoprotein IIb/IIIa inhibitor is feasible and can reduce thrombus burden before percutaneous SVG intervention. METHODS: We performed a multicenter pilot study of abciximab (0.25 mg/kg) given by local delivery catheter before percutaneous intervention for de novo SVG stenoses followed by intravenous infusion. All patients (n = 58) had >/=60% stenosis and Thrombolysis In Myocardial Infarction (TIMI) grade >0 flow in an SVG of 3 to 4 mm in diameter. Percent diameter stenosis, TIMI thrombus grade, and TIMI flow grade were measured before and after delivery of abciximab and after intervention. RESULTS: Median percent diameter stenosis improved from 69% to 45% (P =.0001) after local delivery, and TIMI thrombus grade >/=1 incidence reduced from 68% to 34% (P =.0001). TIMI flow grade was not significantly affected (P =.12). All patients had a successful intervention (

Duke Scholars

Published In

Am Heart J

DOI

ISSN

0002-8703

Publication Date

May 2000

Volume

139

Issue

5

Start / End Page

824 / 829

Location

United States

Related Subject Headings

  • Veins
  • Treatment Outcome
  • Stents
  • Premedication
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Platelet Aggregation Inhibitors
  • Pilot Projects
  • Middle Aged
  • Male
  • Infusion Pumps
 

Citation

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Barsness, G. W., Buller, C., Ohman, E. M., Schechter, E., Pucillo, A., Taylor, M. A., … Holmes, D. R. (2000). Reduced thrombus burden with abciximab delivered locally before percutaneous intervention in saphenous vein grafts. Am Heart J, 139(5), 824–829. https://doi.org/10.1016/s0002-8703(00)90014-0
Barsness, G. W., C. Buller, E. M. Ohman, E. Schechter, A. Pucillo, M. A. Taylor, M. J. Miller, et al. “Reduced thrombus burden with abciximab delivered locally before percutaneous intervention in saphenous vein grafts.Am Heart J 139, no. 5 (May 2000): 824–29. https://doi.org/10.1016/s0002-8703(00)90014-0.
Barsness GW, Buller C, Ohman EM, Schechter E, Pucillo A, Taylor MA, et al. Reduced thrombus burden with abciximab delivered locally before percutaneous intervention in saphenous vein grafts. Am Heart J. 2000 May;139(5):824–9.
Barsness, G. W., et al. “Reduced thrombus burden with abciximab delivered locally before percutaneous intervention in saphenous vein grafts.Am Heart J, vol. 139, no. 5, May 2000, pp. 824–29. Pubmed, doi:10.1016/s0002-8703(00)90014-0.
Barsness GW, Buller C, Ohman EM, Schechter E, Pucillo A, Taylor MA, Miller MJ, Reiner JS, Churchill D, Chandler AB, Gonzalez M, Smith J, Tommaso C, Berdan LG, Wildermann NM, Hasdai D, Holmes DR. Reduced thrombus burden with abciximab delivered locally before percutaneous intervention in saphenous vein grafts. Am Heart J. 2000 May;139(5):824–829.
Journal cover image

Published In

Am Heart J

DOI

ISSN

0002-8703

Publication Date

May 2000

Volume

139

Issue

5

Start / End Page

824 / 829

Location

United States

Related Subject Headings

  • Veins
  • Treatment Outcome
  • Stents
  • Premedication
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Platelet Aggregation Inhibitors
  • Pilot Projects
  • Middle Aged
  • Male
  • Infusion Pumps