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Plasma prostaglandin F 2-alpha levels in dysmenorrehic women.

Publication ,  Journal Article
Shangold, MM; Aksel, S; Schomberg, DW; Hammond, CB
Published in: Fertil Steril
October 1976

Plasma prostaglandin F 2-alpha (PGF 2-alpha) concentrations were compared in nine ovulatory dysmenorrheic women, one dysmenorrheic oral contraceptive user, and two nondysmenorrheic control subjects, in an effort to demonstrate a relationship between plasma PGF 2-alpha levels and dysmenorrhea. In addition, the effects of aspirin, a known inhibitorof prostaglandins synthesis, on dysmenorrhea and on PGF 2-alpha levels were investigated. No statistical difference was demonstrated between the plasma PGF 2-alpha levels of dysmenorrheic and nondysmenorrheic subjects throughout the menstrual cycle. Attainment of an adequate salicylate level was accompanied by a significant decrease in PGF 2-alpha levels. All dysmenorrheic subjects reported improvement in symptoms while taking aspirin. The greatest subjective relief was reported by women who began taking aspirin (10 grains every 4 hours) 3 or more days prior to the onset of bleeding.

Duke Scholars

Published In

Fertil Steril

ISSN

0015-0282

Publication Date

October 1976

Volume

27

Issue

10

Start / End Page

1171 / 1175

Location

United States

Related Subject Headings

  • Prostaglandins F
  • Progestins
  • Obstetrics & Reproductive Medicine
  • Menstruation
  • Luteinizing Hormone
  • Humans
  • Female
  • Dysmenorrhea
  • Aspirin
  • Adult
 

Citation

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Shangold, M. M., Aksel, S., Schomberg, D. W., & Hammond, C. B. (1976). Plasma prostaglandin F 2-alpha levels in dysmenorrehic women. Fertil Steril, 27(10), 1171–1175.
Shangold, M. M., S. Aksel, D. W. Schomberg, and C. B. Hammond. “Plasma prostaglandin F 2-alpha levels in dysmenorrehic women.Fertil Steril 27, no. 10 (October 1976): 1171–75.
Shangold MM, Aksel S, Schomberg DW, Hammond CB. Plasma prostaglandin F 2-alpha levels in dysmenorrehic women. Fertil Steril. 1976 Oct;27(10):1171–5.
Shangold, M. M., et al. “Plasma prostaglandin F 2-alpha levels in dysmenorrehic women.Fertil Steril, vol. 27, no. 10, Oct. 1976, pp. 1171–75.
Shangold MM, Aksel S, Schomberg DW, Hammond CB. Plasma prostaglandin F 2-alpha levels in dysmenorrehic women. Fertil Steril. 1976 Oct;27(10):1171–1175.

Published In

Fertil Steril

ISSN

0015-0282

Publication Date

October 1976

Volume

27

Issue

10

Start / End Page

1171 / 1175

Location

United States

Related Subject Headings

  • Prostaglandins F
  • Progestins
  • Obstetrics & Reproductive Medicine
  • Menstruation
  • Luteinizing Hormone
  • Humans
  • Female
  • Dysmenorrhea
  • Aspirin
  • Adult