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Reduction of granulosa cell progesterone secretion in vitro by intraovarian implants of antiandrogen.

Publication ,  Journal Article
Schomberg, DW; Williams, RF; Tyrey, L; Ulberg, LC
Published in: Endocrinology
March 1978

Intra-ovarian Silastic implants containing the antiandrogen, Flutamide, or its active metabolite, reduced the level of progesterone secretion in porcine granulosa cell cultures by approximately 50%. These results complement recent observations in vitro suggesting a role for androgen in granulosa cell steroidogenesis during follicular development.

Duke Scholars

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

March 1978

Volume

102

Issue

3

Start / End Page

984 / 987

Location

United States

Related Subject Headings

  • Swine
  • Progesterone
  • Ovary
  • Granulosa Cells
  • Flutamide
  • Female
  • Endocrinology & Metabolism
  • Drug Implants
  • Animals
  • Anilides
 

Citation

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Schomberg, D. W., Williams, R. F., Tyrey, L., & Ulberg, L. C. (1978). Reduction of granulosa cell progesterone secretion in vitro by intraovarian implants of antiandrogen. Endocrinology, 102(3), 984–987. https://doi.org/10.1210/endo-102-3-984
Schomberg, D. W., R. F. Williams, L. Tyrey, and L. C. Ulberg. “Reduction of granulosa cell progesterone secretion in vitro by intraovarian implants of antiandrogen.Endocrinology 102, no. 3 (March 1978): 984–87. https://doi.org/10.1210/endo-102-3-984.
Schomberg DW, Williams RF, Tyrey L, Ulberg LC. Reduction of granulosa cell progesterone secretion in vitro by intraovarian implants of antiandrogen. Endocrinology. 1978 Mar;102(3):984–7.
Schomberg, D. W., et al. “Reduction of granulosa cell progesterone secretion in vitro by intraovarian implants of antiandrogen.Endocrinology, vol. 102, no. 3, Mar. 1978, pp. 984–87. Pubmed, doi:10.1210/endo-102-3-984.
Schomberg DW, Williams RF, Tyrey L, Ulberg LC. Reduction of granulosa cell progesterone secretion in vitro by intraovarian implants of antiandrogen. Endocrinology. 1978 Mar;102(3):984–987.
Journal cover image

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

March 1978

Volume

102

Issue

3

Start / End Page

984 / 987

Location

United States

Related Subject Headings

  • Swine
  • Progesterone
  • Ovary
  • Granulosa Cells
  • Flutamide
  • Female
  • Endocrinology & Metabolism
  • Drug Implants
  • Animals
  • Anilides