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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.

Publication ,  Journal Article
Lindsten, T; Ross, AJ; King, A; Zong, WX; Rathmell, JC; Shiels, HA; Ulrich, E; Waymire, KG; Mahar, P; Frauwirth, K; Chen, Y; Wei, M; Eng, VM ...
Published in: Mol Cell
December 2000

Proapoptotic Bcl-2 family members have been proposed to play a central role in regulating apoptosis. However, mice lacking bax display limited phenotypic abnormalities. As presented here, bak(-/-) mice were found to be developmentally normal and reproductively fit and failed to develop any age-related disorders. However, when Bak-deficient mice were mated to Bax-deficient mice to create mice lacking both genes, the majority of bax(-/-)bak(-/-) animals died perinatally with fewer than 10% surviving into adulthood. bax(-/-)bak(-/-) mice displayed multiple developmental defects, including persistence of interdigital webs, an imperforate vaginal canal, and accumulation of excess cells within both the central nervous and hematopoietic systems. Thus, Bax and Bak have overlapping roles in the regulation of apoptosis during mammalian development and tissue homeostasis.

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Published In

Mol Cell

DOI

ISSN

1097-2765

Publication Date

December 2000

Volume

6

Issue

6

Start / End Page

1389 / 1399

Location

United States

Related Subject Headings

  • fas Receptor
  • bcl-2-Associated X Protein
  • bcl-2 Homologous Antagonist-Killer Protein
  • Thymus Gland
  • Spleen
  • Proto-Oncogene Proteins c-bcl-2
  • Proto-Oncogene Proteins
  • Phenotype
  • Mice, Knockout
  • Mice
 

Citation

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Lindsten, T., Ross, A. J., King, A., Zong, W. X., Rathmell, J. C., Shiels, H. A., … Thompson, C. B. (2000). The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell, 6(6), 1389–1399. https://doi.org/10.1016/s1097-2765(00)00136-2
Lindsten, T., A. J. Ross, A. King, W. X. Zong, J. C. Rathmell, H. A. Shiels, E. Ulrich, et al. “The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.Mol Cell 6, no. 6 (December 2000): 1389–99. https://doi.org/10.1016/s1097-2765(00)00136-2.
Lindsten T, Ross AJ, King A, Zong WX, Rathmell JC, Shiels HA, et al. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell. 2000 Dec;6(6):1389–99.
Lindsten, T., et al. “The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.Mol Cell, vol. 6, no. 6, Dec. 2000, pp. 1389–99. Pubmed, doi:10.1016/s1097-2765(00)00136-2.
Lindsten T, Ross AJ, King A, Zong WX, Rathmell JC, Shiels HA, Ulrich E, Waymire KG, Mahar P, Frauwirth K, Chen Y, Wei M, Eng VM, Adelman DM, Simon MC, Ma A, Golden JA, Evan G, Korsmeyer SJ, MacGregor GR, Thompson CB. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell. 2000 Dec;6(6):1389–1399.
Journal cover image

Published In

Mol Cell

DOI

ISSN

1097-2765

Publication Date

December 2000

Volume

6

Issue

6

Start / End Page

1389 / 1399

Location

United States

Related Subject Headings

  • fas Receptor
  • bcl-2-Associated X Protein
  • bcl-2 Homologous Antagonist-Killer Protein
  • Thymus Gland
  • Spleen
  • Proto-Oncogene Proteins c-bcl-2
  • Proto-Oncogene Proteins
  • Phenotype
  • Mice, Knockout
  • Mice