Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations.

Publication ,  Journal Article
McCarthy, JJ; Lewitzky, S; Reeves, C; Permutt, A; Glaser, B; Groop, LC; Lehner, T; Meyer, JM
Published in: Hum Hered
2003

OBJECTIVE: We examined polymorphisms in the HDL receptor, SR-BI, for association with plasma HDL cholesterol levels. METHODS: Study subjects, including 847 women and 725 men, were from families originally ascertained for type 2 diabetes from Finland, Sweden and Israel. Four common polymorphisms were examined in linear regression analysis: an exon 1 missense (EX1), exon 8 silent (EX8), intron 5 (IVS5) and intron 10 (IVS10) variants. RESULTS: Genotype combinations for the three polymorphisms in linkage disequilibrium (IVS5, EX8 and IVS10) were found to be associated with HDL-C among women from the Israeli (p = 0.01) and Swedish (p = 0.06) populations. In Finnish women, the association was only apparent after taking into account effect modification by triglyceride levels (p = 0.04). One specific pattern of genotypes, denoted by presence of the IVS5_T and EX8_C alleles, and absence of the IVS10_G allele, was consistently associated with the lowest mean levels of HDL-C in women from all three populations. These same associations were not found in men. CONCLUSIONS: Polymorphic variation of the SR-BI gene may influence HDL-C levels and act in a sex-dependent manner.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Hum Hered

DOI

ISSN

0001-5652

Publication Date

2003

Volume

55

Issue

4

Start / End Page

163 / 170

Location

Switzerland

Related Subject Headings

  • Sweden
  • Receptors, Scavenger
  • Receptors, Immunologic
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Linkage Disequilibrium
  • Israel
  • Humans
  • Genotype
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McCarthy, J. J., Lewitzky, S., Reeves, C., Permutt, A., Glaser, B., Groop, L. C., … Meyer, J. M. (2003). Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations. Hum Hered, 55(4), 163–170. https://doi.org/10.1159/000073986
McCarthy, Jeanette J., Steve Lewitzky, Cynthia Reeves, Alan Permutt, Benjamin Glaser, Leif C. Groop, Thomas Lehner, and Joanne M. Meyer. “Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations.Hum Hered 55, no. 4 (2003): 163–70. https://doi.org/10.1159/000073986.
McCarthy JJ, Lewitzky S, Reeves C, Permutt A, Glaser B, Groop LC, et al. Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations. Hum Hered. 2003;55(4):163–70.
McCarthy, Jeanette J., et al. “Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations.Hum Hered, vol. 55, no. 4, 2003, pp. 163–70. Pubmed, doi:10.1159/000073986.
McCarthy JJ, Lewitzky S, Reeves C, Permutt A, Glaser B, Groop LC, Lehner T, Meyer JM. Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations. Hum Hered. 2003;55(4):163–170.
Journal cover image

Published In

Hum Hered

DOI

ISSN

0001-5652

Publication Date

2003

Volume

55

Issue

4

Start / End Page

163 / 170

Location

Switzerland

Related Subject Headings

  • Sweden
  • Receptors, Scavenger
  • Receptors, Immunologic
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Linkage Disequilibrium
  • Israel
  • Humans
  • Genotype