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Short-term effects of formaldehyde on peak expiratory flow and irritant symptoms.

Publication ,  Journal Article
Kriebel, D; Myers, D; Cheng, M; Woskie, S; Cocanour, B
Published in: Arch Environ Health
2001

The authors studied the respiratory effects of formaldehyde exposure among students who dissected cadavers in a gross anatomy laboratory. Peak expiratory flow and respiratory symptoms were measured before and after each weekly laboratory session. Each of 38 students was exposed to formaldehyde for 2.5 hr/wk for 14 wk. Individual, daily formaldehyde measurements averaged 1.1 ppm (standard deviation = 0.56 ppm). Multivariate models demonstrated two different time scales of effect of formaldehyde on peak expiratory flow: (1) exposure during the previous 2.5 hr reduced peak expiratory flow by -1.0% per ppm, and (2) average exposure during all preceding weeks reduced peak expiratory flow by an additional -0.5% per ppm of formaldehyde. However, the short-term exposure effect was diminished during the first 4 wk, suggesting at least partial acclimatization. Symptom reporting was also associated with exposure during the previous 2.5 hr, and similar evidence of acclimatization was observed. These results suggest that there are two different time scales of response to formaldehyde, and they emphasize the need for longitudinal studies, characterized by quantitative exposure characterization, and frequent measurements of outcome.

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Published In

Arch Environ Health

DOI

ISSN

0003-9896

Publication Date

2001

Volume

56

Issue

1

Start / End Page

11 / 18

Location

United States

Related Subject Headings

  • Vital Capacity
  • Toxicology
  • Time Factors
  • Surveys and Questionnaires
  • Students, Health Occupations
  • Sneezing
  • Regression Analysis
  • Physical Therapy Modalities
  • Peak Expiratory Flow Rate
  • Occupational Exposure
 

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Kriebel, D., Myers, D., Cheng, M., Woskie, S., & Cocanour, B. (2001). Short-term effects of formaldehyde on peak expiratory flow and irritant symptoms. Arch Environ Health, 56(1), 11–18. https://doi.org/10.1080/00039890109604049
Kriebel, D., D. Myers, M. Cheng, S. Woskie, and B. Cocanour. “Short-term effects of formaldehyde on peak expiratory flow and irritant symptoms.Arch Environ Health 56, no. 1 (2001): 11–18. https://doi.org/10.1080/00039890109604049.
Kriebel D, Myers D, Cheng M, Woskie S, Cocanour B. Short-term effects of formaldehyde on peak expiratory flow and irritant symptoms. Arch Environ Health. 2001;56(1):11–8.
Kriebel, D., et al. “Short-term effects of formaldehyde on peak expiratory flow and irritant symptoms.Arch Environ Health, vol. 56, no. 1, 2001, pp. 11–18. Pubmed, doi:10.1080/00039890109604049.
Kriebel D, Myers D, Cheng M, Woskie S, Cocanour B. Short-term effects of formaldehyde on peak expiratory flow and irritant symptoms. Arch Environ Health. 2001;56(1):11–18.

Published In

Arch Environ Health

DOI

ISSN

0003-9896

Publication Date

2001

Volume

56

Issue

1

Start / End Page

11 / 18

Location

United States

Related Subject Headings

  • Vital Capacity
  • Toxicology
  • Time Factors
  • Surveys and Questionnaires
  • Students, Health Occupations
  • Sneezing
  • Regression Analysis
  • Physical Therapy Modalities
  • Peak Expiratory Flow Rate
  • Occupational Exposure