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New roles for pyruvate kinase M2: working out the Warburg effect.

Publication ,  Journal Article
Ferguson, EC; Rathmell, JC
Published in: Trends Biochem Sci
August 2008

The origins and role of the Warburg effect have remained uncertain for many years. Two recent studies demonstrate that an embryonic- and cancer-cell-specific isoform of the enzyme pyruvate kinase M2 (PKM2) is regulated by binding to phospho-tyrosine motifs and promotes increased cell growth and tumor development. PKM2 enhances the use of glycolytic intermediates for macromolecular biosynthesis and tumor growth. These findings illustrate the distinct advantages of this metabolic phenotype in cancer cell growth.

Duke Scholars

Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

August 2008

Volume

33

Issue

8

Start / End Page

359 / 362

Location

England

Related Subject Headings

  • Pyruvate Kinase
  • Neoplasms
  • Humans
  • Developmental Biology
  • Cell Division
  • Binding Sites
  • Animals
  • 3404 Medicinal and biomolecular chemistry
  • 3205 Medical biochemistry and metabolomics
  • 3101 Biochemistry and cell biology
 

Citation

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ICMJE
MLA
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Ferguson, E. C., & Rathmell, J. C. (2008). New roles for pyruvate kinase M2: working out the Warburg effect. Trends Biochem Sci, 33(8), 359–362. https://doi.org/10.1016/j.tibs.2008.05.006
Ferguson, Emily C., and Jeffrey C. Rathmell. “New roles for pyruvate kinase M2: working out the Warburg effect.Trends Biochem Sci 33, no. 8 (August 2008): 359–62. https://doi.org/10.1016/j.tibs.2008.05.006.
Ferguson EC, Rathmell JC. New roles for pyruvate kinase M2: working out the Warburg effect. Trends Biochem Sci. 2008 Aug;33(8):359–62.
Ferguson, Emily C., and Jeffrey C. Rathmell. “New roles for pyruvate kinase M2: working out the Warburg effect.Trends Biochem Sci, vol. 33, no. 8, Aug. 2008, pp. 359–62. Pubmed, doi:10.1016/j.tibs.2008.05.006.
Ferguson EC, Rathmell JC. New roles for pyruvate kinase M2: working out the Warburg effect. Trends Biochem Sci. 2008 Aug;33(8):359–362.
Journal cover image

Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

August 2008

Volume

33

Issue

8

Start / End Page

359 / 362

Location

England

Related Subject Headings

  • Pyruvate Kinase
  • Neoplasms
  • Humans
  • Developmental Biology
  • Cell Division
  • Binding Sites
  • Animals
  • 3404 Medicinal and biomolecular chemistry
  • 3205 Medical biochemistry and metabolomics
  • 3101 Biochemistry and cell biology