New roles for pyruvate kinase M2: working out the Warburg effect.
Publication
, Journal Article
Ferguson, EC; Rathmell, JC
Published in: Trends Biochem Sci
August 2008
The origins and role of the Warburg effect have remained uncertain for many years. Two recent studies demonstrate that an embryonic- and cancer-cell-specific isoform of the enzyme pyruvate kinase M2 (PKM2) is regulated by binding to phospho-tyrosine motifs and promotes increased cell growth and tumor development. PKM2 enhances the use of glycolytic intermediates for macromolecular biosynthesis and tumor growth. These findings illustrate the distinct advantages of this metabolic phenotype in cancer cell growth.
Duke Scholars
Published In
Trends Biochem Sci
DOI
ISSN
0968-0004
Publication Date
August 2008
Volume
33
Issue
8
Start / End Page
359 / 362
Location
England
Related Subject Headings
- Pyruvate Kinase
- Neoplasms
- Humans
- Developmental Biology
- Cell Division
- Binding Sites
- Animals
- 3404 Medicinal and biomolecular chemistry
- 3205 Medical biochemistry and metabolomics
- 3101 Biochemistry and cell biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Ferguson, E. C., & Rathmell, J. C. (2008). New roles for pyruvate kinase M2: working out the Warburg effect. Trends Biochem Sci, 33(8), 359–362. https://doi.org/10.1016/j.tibs.2008.05.006
Ferguson, Emily C., and Jeffrey C. Rathmell. “New roles for pyruvate kinase M2: working out the Warburg effect.” Trends Biochem Sci 33, no. 8 (August 2008): 359–62. https://doi.org/10.1016/j.tibs.2008.05.006.
Ferguson EC, Rathmell JC. New roles for pyruvate kinase M2: working out the Warburg effect. Trends Biochem Sci. 2008 Aug;33(8):359–62.
Ferguson, Emily C., and Jeffrey C. Rathmell. “New roles for pyruvate kinase M2: working out the Warburg effect.” Trends Biochem Sci, vol. 33, no. 8, Aug. 2008, pp. 359–62. Pubmed, doi:10.1016/j.tibs.2008.05.006.
Ferguson EC, Rathmell JC. New roles for pyruvate kinase M2: working out the Warburg effect. Trends Biochem Sci. 2008 Aug;33(8):359–362.
Published In
Trends Biochem Sci
DOI
ISSN
0968-0004
Publication Date
August 2008
Volume
33
Issue
8
Start / End Page
359 / 362
Location
England
Related Subject Headings
- Pyruvate Kinase
- Neoplasms
- Humans
- Developmental Biology
- Cell Division
- Binding Sites
- Animals
- 3404 Medicinal and biomolecular chemistry
- 3205 Medical biochemistry and metabolomics
- 3101 Biochemistry and cell biology