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Giant vacuoles in the lining endothelium of the human Schlemm's canal after topical timolol maleate.

Publication ,  Journal Article
McMenamin, PG; Lee, WR; Grierson, I; Grindle, FC
Published in: Investigative ophthalmology & visual science
March 1983

The outflow system was studied by light microscopy in nine human eyes that were treated with topical timolol maleate (0.5%) prior to enucleation for malignant melanoma of the choroid. The frequency of "giant vacuoles" in the lining endothelium of Schlemm's canal and the diameter of these structures was the same in a control group of eyes as in the timolol-treated series. There was no qualitative difference between the architecture of the meshwork in the control and treated groups. These morphologic findings suggested that timolol had no direct action on the outflow apparatus and did not reflect the intraocular pressure (IOP) lowering effect of the drug. The effects of anesthesia, surgical manipulations, and fixation by immersion may have masked any subtle drug effects.

Published In

Investigative ophthalmology & visual science

ISSN

0146-0404

Publication Date

March 1983

Volume

24

Issue

3

Start / End Page

339 / 342

Location

united states

Related Subject Headings

  • Timolol
  • Sclera
  • Propanolamines
  • Ophthalmology & Optometry
  • In Vitro Techniques
  • Humans
  • Endothelium
  • Aqueous Humor
  • 3212 Ophthalmology and optometry
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McMenamin, P. G., Lee, W. R., Grierson, I., & Grindle, F. C. (1983). Giant vacuoles in the lining endothelium of the human Schlemm's canal after topical timolol maleate. Investigative Ophthalmology & Visual Science, 24(3), 339–342.
McMenamin, P. G., W. R. Lee, I. Grierson, and F. C. Grindle. “Giant vacuoles in the lining endothelium of the human Schlemm's canal after topical timolol maleate.Investigative Ophthalmology & Visual Science 24, no. 3 (March 1983): 339–42.
McMenamin PG, Lee WR, Grierson I, Grindle FC. Giant vacuoles in the lining endothelium of the human Schlemm's canal after topical timolol maleate. Investigative ophthalmology & visual science. 1983 Mar;24(3):339–42.
McMenamin, P. G., et al. “Giant vacuoles in the lining endothelium of the human Schlemm's canal after topical timolol maleate.Investigative Ophthalmology & Visual Science, vol. 24, no. 3, Mar. 1983, pp. 339–42.
McMenamin PG, Lee WR, Grierson I, Grindle FC. Giant vacuoles in the lining endothelium of the human Schlemm's canal after topical timolol maleate. Investigative ophthalmology & visual science. 1983 Mar;24(3):339–342.

Published In

Investigative ophthalmology & visual science

ISSN

0146-0404

Publication Date

March 1983

Volume

24

Issue

3

Start / End Page

339 / 342

Location

united states

Related Subject Headings

  • Timolol
  • Sclera
  • Propanolamines
  • Ophthalmology & Optometry
  • In Vitro Techniques
  • Humans
  • Endothelium
  • Aqueous Humor
  • 3212 Ophthalmology and optometry
  • 11 Medical and Health Sciences