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Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit.

Publication ,  Journal Article
Dempster, AG; Lee, WR; Bahnasawi, S; Downie, T
Published in: Graefes Arch Clin Exp Ophthalmol
1983

An orbital embryonal rhabdomyosarcoma, which was excised from the orbit of an 8-year-old girl, was studied by light microscopy and transmission electron microscopy. Cells within the tumour demonstrated by light microscopy diffuse areas of necrosis and isolated single-cell necrosis. There were many viable tumour cells with intracytoplasmic vacuolar structures which contained basophilic granules. Ultrastructural studies showed close apposition between well-preserved tumour rhabdomyoblasts and degenerate or necrotic tumour cells: degenerate cells and condensed cell fragments were observed within the cytoplasm of the well-preserved tumour cells. Some cells which showed degenerative changes had features which suggested that they had ingested more than one degenerate cell on separate occasions. This phenomenon may be regarded as a variant of selective individual cell death, currently referred to as apoptosis, which has not been previously reported in a case of embryonal rhabdomyosarcoma. The patient remains free of tumour recurrence four years following treatment with combined radiotherapy and chemotherapy.

Duke Scholars

Published In

Graefes Arch Clin Exp Ophthalmol

DOI

ISSN

0721-832X

Publication Date

1983

Volume

221

Issue

2

Start / End Page

89 / 95

Location

Germany

Related Subject Headings

  • Rhabdomyosarcoma
  • Orbital Neoplasms
  • Ophthalmology & Optometry
  • Necrosis
  • Humans
  • Female
  • Endocytosis
  • Combined Modality Therapy
  • Child
  • Cell Survival
 

Citation

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Dempster, A. G., Lee, W. R., Bahnasawi, S., & Downie, T. (1983). Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit. Graefes Arch Clin Exp Ophthalmol, 221(2), 89–95. https://doi.org/10.1007/BF02133814
Dempster, A. G., W. R. Lee, S. Bahnasawi, and T. Downie. “Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit.Graefes Arch Clin Exp Ophthalmol 221, no. 2 (1983): 89–95. https://doi.org/10.1007/BF02133814.
Dempster AG, Lee WR, Bahnasawi S, Downie T. Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit. Graefes Arch Clin Exp Ophthalmol. 1983;221(2):89–95.
Dempster, A. G., et al. “Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit.Graefes Arch Clin Exp Ophthalmol, vol. 221, no. 2, 1983, pp. 89–95. Pubmed, doi:10.1007/BF02133814.
Dempster AG, Lee WR, Bahnasawi S, Downie T. Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit. Graefes Arch Clin Exp Ophthalmol. 1983;221(2):89–95.
Journal cover image

Published In

Graefes Arch Clin Exp Ophthalmol

DOI

ISSN

0721-832X

Publication Date

1983

Volume

221

Issue

2

Start / End Page

89 / 95

Location

Germany

Related Subject Headings

  • Rhabdomyosarcoma
  • Orbital Neoplasms
  • Ophthalmology & Optometry
  • Necrosis
  • Humans
  • Female
  • Endocytosis
  • Combined Modality Therapy
  • Child
  • Cell Survival