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Vasodilator administration in the presence of beta-adrenergic blockade.

Publication ,  Journal Article
Mroczek, WJ; Lee, WR; Davidov, ME; Finnerty, FA
Published in: Circulation
June 1976

To explore the possibility that the presence of propranolol-induced beta-adrenergic blockade might have an adverse effect upon homeostatic circulatory reflexes activated by the administration of a potent vasodilator agent, arterial blood pressure and pulse rate response to rapid intravenous diazoxide injection was monitored before and after pretreatment with propranolol in ten hypertensive patients. It appeared that beta-adrenergic blockade had no clinically significant effect on the magnitude of hypotension or the degree of heart rate acceleration induced by the administration of the potent vasodilator diazoxide. This reflex vasodilator-induced cardio-acceleration after propranolol adminstration could be the result of incomplete blockade of endogenously released neurotransmitter, inhibition of the parasympathetic nervous system, or a direct pharmacologic action of diazoxide. Diazoxide administration to hypertensive patients in the presence of beta-adrenergic blockade was not associated with any clinically significant hemodynamic consequences.

Published In

Circulation

ISSN

0009-7322

Publication Date

June 1976

Volume

53

Issue

6

Start / End Page

985 / 988

Location

united states

Related Subject Headings

  • Vasodilator Agents
  • Propranolol
  • Premedication
  • Patient Compliance
  • Middle Aged
  • Male
  • Injections, Intravenous
  • Hypertension
  • Humans
  • Human Experimentation
 

Citation

APA
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ICMJE
MLA
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Mroczek, W. J., Lee, W. R., Davidov, M. E., & Finnerty, F. A. (1976). Vasodilator administration in the presence of beta-adrenergic blockade. Circulation, 53(6), 985–988.
Mroczek, W. J., W. R. Lee, M. E. Davidov, and F. A. Finnerty. “Vasodilator administration in the presence of beta-adrenergic blockade.Circulation 53, no. 6 (June 1976): 985–88.
Mroczek WJ, Lee WR, Davidov ME, Finnerty FA. Vasodilator administration in the presence of beta-adrenergic blockade. Circulation. 1976 Jun;53(6):985–8.
Mroczek, W. J., et al. “Vasodilator administration in the presence of beta-adrenergic blockade.Circulation, vol. 53, no. 6, June 1976, pp. 985–88.
Mroczek WJ, Lee WR, Davidov ME, Finnerty FA. Vasodilator administration in the presence of beta-adrenergic blockade. Circulation. 1976 Jun;53(6):985–988.

Published In

Circulation

ISSN

0009-7322

Publication Date

June 1976

Volume

53

Issue

6

Start / End Page

985 / 988

Location

united states

Related Subject Headings

  • Vasodilator Agents
  • Propranolol
  • Premedication
  • Patient Compliance
  • Middle Aged
  • Male
  • Injections, Intravenous
  • Hypertension
  • Humans
  • Human Experimentation