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Sexual dimorphism of urine angiotensinogen excretion in the rat.

Publication ,  Journal Article
Wang, E; Yayama, K; Takano, M; Okamoto, H
Published in: Jpn J Pharmacol
April 1994

To determine the source of angiotensinogen excreted in urine, urine angiotensinogen was measured in male and female rats during growth. Angiotensinogen in 24-hr urine, measured by direct radioimmunoassay with antibody against rat angiotensinogen, increased fourfold in males between the ages of 5 and 7 weeks, whereas no significant changes were observed in females or castrated males. Plasma levels of angiotensinogen, in contrast, showed no significant differences between these groups at any age. Castration of adult males caused a significant reduction of urinary angiotensinogen after 4 weeks. Consecutive s.c. administration of 17 alpha-methyltestosterone for 3 weeks in castrated males resulted in a threefold increase in the urinary excretion of angiotensinogen, as well as a twofold increase in the renal expression of angiotensinogen messenger RNA (mRNA). Renal levels of angiotensinogen mRNA in intact adult males were about threefold higher than those in females and castrated males, whereas there were no significant differences in hepatic angiotensinogen mRNA between these animals. These results suggest that the sexual differences in the urinary excretion of angiotensinogen are primarily due to the androgen-dependent dimorphic expression of angiotensinogen mRNA in the kidney; thus, levels of angiotensinogen in urine might reflect intrarenal production.

Published In

Jpn J Pharmacol

DOI

ISSN

0021-5198

Publication Date

April 1994

Volume

64

Issue

4

Start / End Page

243 / 250

Location

Japan

Related Subject Headings

  • Sex Characteristics
  • Rats, Sprague-Dawley
  • Rats
  • RNA, Messenger
  • Pharmacology & Pharmacy
  • Methyltestosterone
  • Male
  • Kidney
  • Female
  • Castration
 

Citation

APA
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ICMJE
MLA
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Wang, E., Yayama, K., Takano, M., & Okamoto, H. (1994). Sexual dimorphism of urine angiotensinogen excretion in the rat. Jpn J Pharmacol, 64(4), 243–250. https://doi.org/10.1254/jjp.64.243
Wang, E., K. Yayama, M. Takano, and H. Okamoto. “Sexual dimorphism of urine angiotensinogen excretion in the rat.Jpn J Pharmacol 64, no. 4 (April 1994): 243–50. https://doi.org/10.1254/jjp.64.243.
Wang E, Yayama K, Takano M, Okamoto H. Sexual dimorphism of urine angiotensinogen excretion in the rat. Jpn J Pharmacol. 1994 Apr;64(4):243–50.
Wang, E., et al. “Sexual dimorphism of urine angiotensinogen excretion in the rat.Jpn J Pharmacol, vol. 64, no. 4, Apr. 1994, pp. 243–50. Pubmed, doi:10.1254/jjp.64.243.
Wang E, Yayama K, Takano M, Okamoto H. Sexual dimorphism of urine angiotensinogen excretion in the rat. Jpn J Pharmacol. 1994 Apr;64(4):243–250.

Published In

Jpn J Pharmacol

DOI

ISSN

0021-5198

Publication Date

April 1994

Volume

64

Issue

4

Start / End Page

243 / 250

Location

Japan

Related Subject Headings

  • Sex Characteristics
  • Rats, Sprague-Dawley
  • Rats
  • RNA, Messenger
  • Pharmacology & Pharmacy
  • Methyltestosterone
  • Male
  • Kidney
  • Female
  • Castration