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Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma.

Publication ,  Journal Article
DeLorenze, GN; McCoy, L; Tsai, A-L; Quesenberry, CP; Rice, T; Il'yasova, D; Wrensch, M
Published in: BMC Cancer
May 19, 2010

BACKGROUND: Malignant glioma is a rare cancer with poor survival. The influence of diet and antioxidant intake on glioma survival is not well understood. The current study examines the association between antioxidant intake and survival after glioma diagnosis. METHODS: Adult patients diagnosed with malignant glioma during 1991-1994 and 1997-2001 were enrolled in a population-based study. Diagnosis was confirmed by review of pathology specimens. A modified food-frequency questionnaire interview was completed by each glioma patient or a designated proxy. Intake of each food item was converted to grams consumed/day. From this nutrient database, 16 antioxidants, calcium, a total antioxidant index and 3 macronutrients were available for survival analysis. Cox regression estimated mortality hazard ratios associated with each nutrient and the antioxidant index adjusting for potential confounders. Nutrient values were categorized into tertiles. Models were stratified by histology (Grades II, III, and IV) and conducted for all (including proxy) subjects and for a subset of self-reported subjects. RESULTS: Geometric mean values for 11 fat-soluble and 6 water-soluble individual antioxidants, antioxidant index and 3 macronutrients were virtually the same when comparing all cases (n=748) to self-reported cases only (n=450). For patients diagnosed with Grade II and Grade III histology, moderate (915.8-2118.3 mcg) intake of fat-soluble lycopene was associated with poorer survival when compared to low intake (0.0-914.8 mcg), for self-reported cases only. High intake of vitamin E and moderate/high intake of secoisolariciresinol among Grade III patients indicated greater survival for all cases. In Grade IV patients, moderate/high intake of cryptoxanthin and high intake of secoisolariciresinol were associated with poorer survival among all cases. Among Grade II patients, moderate intake of water-soluble folate was associated with greater survival for all cases; high intake of vitamin C and genistein and the highest level of the antioxidant index were associated with poorer survival for all cases. CONCLUSIONS: The associations observed in our study suggest that the influence of some antioxidants on survival following a diagnosis of malignant glioma are inconsistent and vary by histology group. Further research in a large sample of glioma patients is needed to confirm/refute our results.

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Published In

BMC Cancer

DOI

EISSN

1471-2407

Publication Date

May 19, 2010

Volume

10

Start / End Page

215

Location

England

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • SEER Program
  • Risk Factors
  • Risk Assessment
  • Proportional Hazards Models
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Male
 

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DeLorenze, G. N., McCoy, L., Tsai, A.-L., Quesenberry, C. P., Rice, T., Il’yasova, D., & Wrensch, M. (2010). Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma. BMC Cancer, 10, 215. https://doi.org/10.1186/1471-2407-10-215
DeLorenze, Gerald N., Lucie McCoy, Ai-Lin Tsai, Charles P. Quesenberry, Terri Rice, Dora Il’yasova, and Margaret Wrensch. “Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma.BMC Cancer 10 (May 19, 2010): 215. https://doi.org/10.1186/1471-2407-10-215.
DeLorenze GN, McCoy L, Tsai A-L, Quesenberry CP, Rice T, Il’yasova D, et al. Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma. BMC Cancer. 2010 May 19;10:215.
DeLorenze, Gerald N., et al. “Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma.BMC Cancer, vol. 10, May 2010, p. 215. Pubmed, doi:10.1186/1471-2407-10-215.
DeLorenze GN, McCoy L, Tsai A-L, Quesenberry CP, Rice T, Il’yasova D, Wrensch M. Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma. BMC Cancer. 2010 May 19;10:215.
Journal cover image

Published In

BMC Cancer

DOI

EISSN

1471-2407

Publication Date

May 19, 2010

Volume

10

Start / End Page

215

Location

England

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • SEER Program
  • Risk Factors
  • Risk Assessment
  • Proportional Hazards Models
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Male