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α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin.

Publication ,  Journal Article
Ohmatsu, H; Kadono, T; Sugaya, M; Tomita, M; Kai, H; Miyagaki, T; Saeki, H; Tamaki, K; Steeber, DA; Tedder, TF; Sato, S
Published in: J Allergy Clin Immunol
December 2010

BACKGROUND: β7 Integrin, a cell adhesion molecule, is present in the form of α4β7 integrin or αEβ7 integrin. α4β7 Integrin is expressed on most leucocytes and is essential for their migration to gut-associated lymphoid tissues by interacting with its primary ligand, mucosal addressin cell adhesion molecule-1, which is preferentially expressed in gut-associated lymphoid tissues. Although the importance of α4β7 integrin in intestinal inflammation has been established, its role in cutaneous inflammation remains to be elucidated. OBJECTIVE: We sought to investigate the role of β7 integrin in cutaneous inflammation. METHODS: We used a murine contact hypersensitivity model and examined the role of β7 integrin by using β7 integrin-deficient and αE integrin-deficient mice. RESULTS: β7 Integrin-deficient mice, not αE integrin-deficient mice, are defective in contact hypersensitivity responses. β7 Integrin deficiency does not affect irritant contact dermatitis. The distribution, migration, and function of antigen presenting cells from β7 integrin-deficient mice are comparable to those from wild-type mice. Moreover, sensitized β7 integrin-deficient T cells are able to respond to antigen stimuli in vitro and elicit contact hypersensitivity responses when directly injected into the skin. However, they are defective in reaching the skin under inflammatory conditions, resulting in reduced contact hypersensitivity responses when intravenously injected. Furthermore, intraperitoneal injection of anti-α4β7 integrin neutralizing antibody elicit impaired contact hypersensitivity responses. CONCLUSION: α4β7 Integrin contributes to contact hypersensitivity responses by regulating T-cell migration to inflammatory skin.

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Published In

J Allergy Clin Immunol

DOI

EISSN

1097-6825

Publication Date

December 2010

Volume

126

Issue

6

Start / End Page

1267 / 1276

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Skin
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Activation
  • Integrins
  • Immunity, Mucosal
  • Dermatitis, Contact
  • Cells, Cultured
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ohmatsu, H., Kadono, T., Sugaya, M., Tomita, M., Kai, H., Miyagaki, T., … Sato, S. (2010). α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin. J Allergy Clin Immunol, 126(6), 1267–1276. https://doi.org/10.1016/j.jaci.2010.08.048
Ohmatsu, Hanako, Takafumi Kadono, Makoto Sugaya, Manabu Tomita, Hiromichi Kai, Tomomitsu Miyagaki, Hidehisa Saeki, et al. “α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin.J Allergy Clin Immunol 126, no. 6 (December 2010): 1267–76. https://doi.org/10.1016/j.jaci.2010.08.048.
Ohmatsu H, Kadono T, Sugaya M, Tomita M, Kai H, Miyagaki T, et al. α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin. J Allergy Clin Immunol. 2010 Dec;126(6):1267–76.
Ohmatsu, Hanako, et al. “α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin.J Allergy Clin Immunol, vol. 126, no. 6, Dec. 2010, pp. 1267–76. Pubmed, doi:10.1016/j.jaci.2010.08.048.
Ohmatsu H, Kadono T, Sugaya M, Tomita M, Kai H, Miyagaki T, Saeki H, Tamaki K, Steeber DA, Tedder TF, Sato S. α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin. J Allergy Clin Immunol. 2010 Dec;126(6):1267–1276.
Journal cover image

Published In

J Allergy Clin Immunol

DOI

EISSN

1097-6825

Publication Date

December 2010

Volume

126

Issue

6

Start / End Page

1267 / 1276

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Skin
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Activation
  • Integrins
  • Immunity, Mucosal
  • Dermatitis, Contact
  • Cells, Cultured