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PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity.

Publication ,  Journal Article
Nemir, S; Hayenga, HN; West, JL
Published in: Biotechnology and bioengineering
February 2010

The ability of cells to migrate in response to mechanical gradients (durotaxis) and differential cell behavior in adhesion, spreading, and proliferation in response to substrate rigidity are key factors both in tissue engineering, in which materials must be selected to provide the appropriate mechanical signals, and in studies of mechanisms of diseases such as cancer and atherosclerosis, in which changes in tissue stiffness may inform cell behavior. Using poly(ethylene glycol) diacrylate hydrogels with varying polymer chain length and photolithographic patterning techniques, we are able to provide substrates with spatially patterned, tunable mechanical properties in both gradients and distinct patterns. The hydrogels can be patterned to produce anisotropic structures and exhibit patterned strain under mechanical loading. These hydrogels may be used to study cell response to substrate rigidity in both two and three dimensions and can also be used as a scaffold in tissue-engineering applications.

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Published In

Biotechnology and bioengineering

DOI

EISSN

1097-0290

ISSN

0006-3592

Publication Date

February 2010

Volume

105

Issue

3

Start / End Page

636 / 644

Related Subject Headings

  • Tissue Engineering
  • Mice
  • Macrophages
  • Hydrogels
  • Elasticity
  • Cell Proliferation
  • Cell Movement
  • Cell Line
  • Cell Culture Techniques
  • Cell Adhesion
 

Citation

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Nemir, S., Hayenga, H. N., & West, J. L. (2010). PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity. Biotechnology and Bioengineering, 105(3), 636–644. https://doi.org/10.1002/bit.22574
Nemir, Stephanie, Heather N. Hayenga, and Jennifer L. West. “PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity.Biotechnology and Bioengineering 105, no. 3 (February 2010): 636–44. https://doi.org/10.1002/bit.22574.
Nemir S, Hayenga HN, West JL. PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity. Biotechnology and bioengineering. 2010 Feb;105(3):636–44.
Nemir, Stephanie, et al. “PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity.Biotechnology and Bioengineering, vol. 105, no. 3, Feb. 2010, pp. 636–44. Epmc, doi:10.1002/bit.22574.
Nemir S, Hayenga HN, West JL. PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity. Biotechnology and bioengineering. 2010 Feb;105(3):636–644.
Journal cover image

Published In

Biotechnology and bioengineering

DOI

EISSN

1097-0290

ISSN

0006-3592

Publication Date

February 2010

Volume

105

Issue

3

Start / End Page

636 / 644

Related Subject Headings

  • Tissue Engineering
  • Mice
  • Macrophages
  • Hydrogels
  • Elasticity
  • Cell Proliferation
  • Cell Movement
  • Cell Line
  • Cell Culture Techniques
  • Cell Adhesion