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Biological correlates of abuse in women with premenstrual dysphoric disorder and healthy controls.

Publication ,  Journal Article
Girdler, SS; Sherwood, A; Hinderliter, AL; Leserman, J; Costello, NL; Straneva, PA; Pedersen, CA; Light, KC
Published in: Psychosom Med
2003

OBJECTIVE: To examine the biological correlates associated with histories of sexual or physical abuse in women meeting DSM criteria for premenstrual dysphoric disorder (PMDD) and in healthy, non-PMDD controls. METHODS: Twenty-eight women with prospectively confirmed PMDD were compared with 28 non-PMDD women for cardiovascular and neuroendocrine measures at rest and in response to mental stressors, and for beta-adrenergic receptor responsivity, during both the follicular and luteal phase of the menstrual cycle. Structured interview was used to assess psychiatric history and prior sexual and physical abuse experiences. All subjects were free of current psychiatric comorbidity and medication use. RESULTS: More PMDD women had prior sexual and physical abuse experiences than controls (20 vs. 10, respectively). Relative to nonabused PMDD women, PMDD women with prior abuse (sexual or physical) exhibited significantly lower resting norepinephrine (NE) levels and significantly greater beta1- and beta2-adrenoceptor responsivity and greater luteal phase NE reactivity to mental stress. For non-PMDD control women, abuse was associated with blunted cortisol, cardiac output, and heart rate reactivity to mental stress relative to nonabused controls. CONCLUSIONS: The results of this initial study suggest that a history of prior abuse is associated with alterations in physiological reactivity to subsequent mental stress in women, but that the biological correlates of abuse may be different for PMDD vs. non-PMDD women.

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Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

2003

Volume

65

Issue

5

Start / End Page

849 / 856

Location

United States

Related Subject Headings

  • Violence
  • Stress, Psychological
  • Sex Offenses
  • Receptors, Adrenergic, beta
  • Psychiatry
  • Prospective Studies
  • Premenstrual Syndrome
  • Norepinephrine
  • Luteal Phase
  • Interview, Psychological
 

Citation

APA
Chicago
ICMJE
MLA
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Girdler, S. S., Sherwood, A., Hinderliter, A. L., Leserman, J., Costello, N. L., Straneva, P. A., … Light, K. C. (2003). Biological correlates of abuse in women with premenstrual dysphoric disorder and healthy controls. Psychosom Med, 65(5), 849–856. https://doi.org/10.1097/01.psy.0000088593.38201.cd
Girdler, Susan S., Andrew Sherwood, Alan L. Hinderliter, Jane Leserman, Nancy L. Costello, Patricia A. Straneva, Cort A. Pedersen, and Kathleen C. Light. “Biological correlates of abuse in women with premenstrual dysphoric disorder and healthy controls.Psychosom Med 65, no. 5 (2003): 849–56. https://doi.org/10.1097/01.psy.0000088593.38201.cd.
Girdler SS, Sherwood A, Hinderliter AL, Leserman J, Costello NL, Straneva PA, et al. Biological correlates of abuse in women with premenstrual dysphoric disorder and healthy controls. Psychosom Med. 2003;65(5):849–56.
Girdler, Susan S., et al. “Biological correlates of abuse in women with premenstrual dysphoric disorder and healthy controls.Psychosom Med, vol. 65, no. 5, 2003, pp. 849–56. Pubmed, doi:10.1097/01.psy.0000088593.38201.cd.
Girdler SS, Sherwood A, Hinderliter AL, Leserman J, Costello NL, Straneva PA, Pedersen CA, Light KC. Biological correlates of abuse in women with premenstrual dysphoric disorder and healthy controls. Psychosom Med. 2003;65(5):849–856.

Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

2003

Volume

65

Issue

5

Start / End Page

849 / 856

Location

United States

Related Subject Headings

  • Violence
  • Stress, Psychological
  • Sex Offenses
  • Receptors, Adrenergic, beta
  • Psychiatry
  • Prospective Studies
  • Premenstrual Syndrome
  • Norepinephrine
  • Luteal Phase
  • Interview, Psychological