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Histopathologic characteristics of two forms of experimental herpes simplex virus retinitis.

Publication ,  Journal Article
Dix, RD; Streilein, JW; Cousins, S; Atherton, SS
Published in: Curr Eye Res
January 1987

Herpes simplex virus type 1 (HSV-1) inoculated intracamerally into one anterior chamber of a BALB/c mouse produces retinitis in the uninoculated contralateral eye within 7 to 10 days while the retina of the inoculated eye is spared. In sharp contrast, animals receiving HSV type 2 (HSV-2) by the anterior chamber route develop a dramatic retinitis in the inoculated eye by day 7 postinoculation while the retina of the contralateral eye remains uninvolved. Histopathologic examination of retinal destruction in the HSV-2-infected ipsilateral eye revealed features which were distinct from those observed in the contralateral eye of HSV-1-infected animals. Whereas HSV-1 produced a rapid, explosive, retinitis which led to destruction of all cell layers of the contralateral retina, HSV-2 induced a retinitis in the ipsilateral eye that was more gradual in onset. Ipsilateral HSV-2 retinitis was characterized initially by disruption of the ganglion and inner nuclear layers which progressed by day 10 to 14 to complete replacement of the retina by a fibrocellular scar. These changes were dominated by a vigorous mononuclear cell infiltrate, a feature not observed in the HSV-1-infected contralateral retinitis. These results suggest that experimental retinitides produced by HSV-1 and HSV-2 are of diverse pathogenesis.

Duke Scholars

Published In

Curr Eye Res

DOI

ISSN

0271-3683

Publication Date

January 1987

Volume

6

Issue

1

Start / End Page

47 / 52

Location

England

Related Subject Headings

  • Retinitis
  • Retina
  • Ophthalmology & Optometry
  • Mice, Inbred BALB C
  • Mice
  • Keratitis, Dendritic
  • Injections
  • Female
  • Anterior Chamber
  • Animals
 

Citation

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ICMJE
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Dix, R. D., Streilein, J. W., Cousins, S., & Atherton, S. S. (1987). Histopathologic characteristics of two forms of experimental herpes simplex virus retinitis. Curr Eye Res, 6(1), 47–52. https://doi.org/10.3109/02713688709020067
Dix, R. D., J. W. Streilein, S. Cousins, and S. S. Atherton. “Histopathologic characteristics of two forms of experimental herpes simplex virus retinitis.Curr Eye Res 6, no. 1 (January 1987): 47–52. https://doi.org/10.3109/02713688709020067.
Dix RD, Streilein JW, Cousins S, Atherton SS. Histopathologic characteristics of two forms of experimental herpes simplex virus retinitis. Curr Eye Res. 1987 Jan;6(1):47–52.
Dix, R. D., et al. “Histopathologic characteristics of two forms of experimental herpes simplex virus retinitis.Curr Eye Res, vol. 6, no. 1, Jan. 1987, pp. 47–52. Pubmed, doi:10.3109/02713688709020067.
Dix RD, Streilein JW, Cousins S, Atherton SS. Histopathologic characteristics of two forms of experimental herpes simplex virus retinitis. Curr Eye Res. 1987 Jan;6(1):47–52.
Journal cover image

Published In

Curr Eye Res

DOI

ISSN

0271-3683

Publication Date

January 1987

Volume

6

Issue

1

Start / End Page

47 / 52

Location

England

Related Subject Headings

  • Retinitis
  • Retina
  • Ophthalmology & Optometry
  • Mice, Inbred BALB C
  • Mice
  • Keratitis, Dendritic
  • Injections
  • Female
  • Anterior Chamber
  • Animals