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Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice.

Publication ,  Journal Article
Liu, S; Suragani, RNVS; Han, A; Zhao, W; Andrews, NC; Chen, J-J
Published in: Haematologica
May 2008

Heme-regulated eIF2alpha kinase (HRI) is essential for regulating globin translation in iron deficiency and in beta-thalassemia. We investigated the role of heme-regulated eIF2alpha kinase in hemoglobin and red blood cell production as well as in iron homeostasis in a mouse model of iron overload. We show that HRI deficiency does not significantly affect red cell parameters of hemochromatosis (HFE(-)(/)(-)) mice. Importantly, heme-regulated eIF2alpha kinase deficiency exacerbates decreases in hepcidin expression and splenic macrophage iron in HFE(-)(/)(-) mice. Furthermore, the serum level of bone morphogenic protein 2, which positively regulates hepcidin, is reduced in heme-regulated eIF2alpha kinase deficiency, but not in HFE deficiency.

Duke Scholars

Published In

Haematologica

DOI

EISSN

1592-8721

Publication Date

May 2008

Volume

93

Issue

5

Start / End Page

753 / 756

Location

Italy

Related Subject Headings

  • eIF-2 Kinase
  • Transforming Growth Factor beta
  • Spleen
  • Protein Serine-Threonine Kinases
  • Phenotype
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Macrophages
  • Iron
 

Citation

APA
Chicago
ICMJE
MLA
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Liu, S., Suragani, R. N. V. S., Han, A., Zhao, W., Andrews, N. C., & Chen, J.-J. (2008). Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice. Haematologica, 93(5), 753–756. https://doi.org/10.3324/haematol.12175
Liu, Sijin, Rajasekhar N. V. S. Suragani, Anping Han, Wanting Zhao, Nancy C. Andrews, and Jane-Jane Chen. “Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice.Haematologica 93, no. 5 (May 2008): 753–56. https://doi.org/10.3324/haematol.12175.
Liu S, Suragani RNVS, Han A, Zhao W, Andrews NC, Chen J-J. Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice. Haematologica. 2008 May;93(5):753–6.
Liu, Sijin, et al. “Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice.Haematologica, vol. 93, no. 5, May 2008, pp. 753–56. Pubmed, doi:10.3324/haematol.12175.
Liu S, Suragani RNVS, Han A, Zhao W, Andrews NC, Chen J-J. Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice. Haematologica. 2008 May;93(5):753–756.

Published In

Haematologica

DOI

EISSN

1592-8721

Publication Date

May 2008

Volume

93

Issue

5

Start / End Page

753 / 756

Location

Italy

Related Subject Headings

  • eIF-2 Kinase
  • Transforming Growth Factor beta
  • Spleen
  • Protein Serine-Threonine Kinases
  • Phenotype
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Macrophages
  • Iron