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An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice.

Publication ,  Journal Article
Roy, CN; Custodio, AO; de Graaf, J; Schneider, S; Akpan, I; Montross, LK; Sanchez, M; Gaudino, A; Hentze, MW; Andrews, NC; Muckenthaler, MU
Published in: Nat Genet
May 2004

Inflammation influences iron balance in the whole organism. A common clinical manifestation of these changes is anemia of chronic disease (ACD; also called anemia of inflammation). Inflammation reduces duodenal iron absorption and increases macrophage iron retention, resulting in low serum iron concentrations (hyposideremia). Despite the protection hyposideremia provides against proliferating microorganisms, this 'iron withholding' reduces the iron available to maturing red blood cells and eventually contributes to the development of anemia. Hepcidin antimicrobial peptide (Hamp) is a hepatic defensin-like peptide hormone that inhibits duodenal iron absorption and macrophage iron release. Hamp is part of the type II acute phase response and is thought to have a crucial regulatory role in sequestering iron in the context of ACD. Mice with deficiencies in the hemochromatosis gene product, Hfe, mounted a general inflammatory response after injection of lipopolysaccharide but lacked appropriate Hamp expression and did not develop hyposideremia. These data suggest a previously unidentified role for Hfe in innate immunity and ACD.

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Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

May 2004

Volume

36

Issue

5

Start / End Page

481 / 485

Location

United States

Related Subject Headings

  • Signal Transduction
  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA, Messenger
  • Oligonucleotide Array Sequence Analysis
  • Mice, Knockout
  • Mice
  • Membrane Proteins
  • Lipopolysaccharides
  • Iron
  • Inflammation
 

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Roy, C. N., Custodio, A. O., de Graaf, J., Schneider, S., Akpan, I., Montross, L. K., … Muckenthaler, M. U. (2004). An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet, 36(5), 481–485. https://doi.org/10.1038/ng1350
Roy, Cindy N., Angel O. Custodio, Jos de Graaf, Susanne Schneider, Imo Akpan, Lynne K. Montross, Mayka Sanchez, et al. “An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice.Nat Genet 36, no. 5 (May 2004): 481–85. https://doi.org/10.1038/ng1350.
Roy CN, Custodio AO, de Graaf J, Schneider S, Akpan I, Montross LK, et al. An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet. 2004 May;36(5):481–5.
Roy, Cindy N., et al. “An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice.Nat Genet, vol. 36, no. 5, May 2004, pp. 481–85. Pubmed, doi:10.1038/ng1350.
Roy CN, Custodio AO, de Graaf J, Schneider S, Akpan I, Montross LK, Sanchez M, Gaudino A, Hentze MW, Andrews NC, Muckenthaler MU. An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet. 2004 May;36(5):481–485.

Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

May 2004

Volume

36

Issue

5

Start / End Page

481 / 485

Location

United States

Related Subject Headings

  • Signal Transduction
  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA, Messenger
  • Oligonucleotide Array Sequence Analysis
  • Mice, Knockout
  • Mice
  • Membrane Proteins
  • Lipopolysaccharides
  • Iron
  • Inflammation