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Novel bacterial P-type ATPases with histidine-rich heavy-metal-associated sequences.

Publication ,  Journal Article
Trenor, C; Lin, W; Andrews, NC
Published in: Biochem Biophys Res Commun
December 30, 1994

Menkes disease and Wilson disease are human disorders of copper metabolism. It has recently been shown that both are due to mutations in P-type ATPase copper transport molecules. Related heavy metal transporting ATPases have been described in several strains of bacteria. In an effort to isolate other mammalian metal transporters, we screened a human small intestine library with probes homologous to conserved sequences in the known proteins. Two novel cDNAs were isolated, which encode new members of this family. Surprisingly, they were both of bacterial origin, most likely derived from E. coli sequences transduced during library construction.

Duke Scholars

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

December 30, 1994

Volume

205

Issue

3

Start / End Page

1644 / 1650

Location

United States

Related Subject Headings

  • Species Specificity
  • Sequence Homology, Amino Acid
  • Molecular Sequence Data
  • Metals
  • Menkes Kinky Hair Syndrome
  • Humans
  • Histidine
  • Hepatolenticular Degeneration
  • Gene Library
  • Escherichia coli
 

Citation

APA
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MLA
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Trenor, C., Lin, W., & Andrews, N. C. (1994). Novel bacterial P-type ATPases with histidine-rich heavy-metal-associated sequences. Biochem Biophys Res Commun, 205(3), 1644–1650. https://doi.org/10.1006/bbrc.1994.2856
Trenor, C., W. Lin, and N. C. Andrews. “Novel bacterial P-type ATPases with histidine-rich heavy-metal-associated sequences.Biochem Biophys Res Commun 205, no. 3 (December 30, 1994): 1644–50. https://doi.org/10.1006/bbrc.1994.2856.
Trenor C, Lin W, Andrews NC. Novel bacterial P-type ATPases with histidine-rich heavy-metal-associated sequences. Biochem Biophys Res Commun. 1994 Dec 30;205(3):1644–50.
Trenor, C., et al. “Novel bacterial P-type ATPases with histidine-rich heavy-metal-associated sequences.Biochem Biophys Res Commun, vol. 205, no. 3, Dec. 1994, pp. 1644–50. Pubmed, doi:10.1006/bbrc.1994.2856.
Trenor C, Lin W, Andrews NC. Novel bacterial P-type ATPases with histidine-rich heavy-metal-associated sequences. Biochem Biophys Res Commun. 1994 Dec 30;205(3):1644–1650.
Journal cover image

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

December 30, 1994

Volume

205

Issue

3

Start / End Page

1644 / 1650

Location

United States

Related Subject Headings

  • Species Specificity
  • Sequence Homology, Amino Acid
  • Molecular Sequence Data
  • Metals
  • Menkes Kinky Hair Syndrome
  • Humans
  • Histidine
  • Hepatolenticular Degeneration
  • Gene Library
  • Escherichia coli