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Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides.

Publication ,  Journal Article
Lee, TT; Kashiwada, Y; Huang, L; Snider, J; Cosentino, M; Lee, KH
Published in: Bioorg Med Chem
October 1994

Suksdorfin (1), which is isolated from the fruit of Lomatium suksdorfii, was found to be able to inhibit HIV-1 replication in the T cell line, H9, with an average EC50 value of 2.6 +/- 2.1 microM. In addition, suksdorfin was also suppressive during acute HIV-1 infections of peripheral blood mononuclear cells, monocyte/macrophages and the promonocytic cell line, U937. Combinations of 1 and the anti-HIV nucleosides ddI and ddC demonstrated statistical synergy in inhibiting HIV-1 replication (ddC > ddI). However, the viral inhibition mediated by combining 1 with AZT was not statistically synergistic. Furthermore, the presence of suksdorfin did not antagonize the suppression mediated by the three nucleoside reverse transcriptase inhibitors. Comparison of the structure and activity of 1 with those of ten related compounds indicated that the dihydroseselin type of pyranocoumarin possessing a 4'-isovaleryl group is important to suksdorfin's enhanced anti-HIV activity.

Duke Scholars

Published In

Bioorg Med Chem

DOI

ISSN

0968-0896

Publication Date

October 1994

Volume

2

Issue

10

Start / End Page

1051 / 1056

Location

England

Related Subject Headings

  • Virus Replication
  • T-Lymphocytes
  • Plants, Medicinal
  • Nucleosides
  • Molecular Structure
  • Medicinal & Biomolecular Chemistry
  • HIV Infections
  • HIV Core Protein p24
  • HIV
  • Enzyme-Linked Immunosorbent Assay
 

Citation

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ICMJE
MLA
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Lee, T. T., Kashiwada, Y., Huang, L., Snider, J., Cosentino, M., & Lee, K. H. (1994). Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides. Bioorg Med Chem, 2(10), 1051–1056. https://doi.org/10.1016/s0968-0896(00)82054-4
Lee, T. T., Y. Kashiwada, L. Huang, J. Snider, M. Cosentino, and K. H. Lee. “Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides.Bioorg Med Chem 2, no. 10 (October 1994): 1051–56. https://doi.org/10.1016/s0968-0896(00)82054-4.
Lee, T. T., et al. “Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides.Bioorg Med Chem, vol. 2, no. 10, Oct. 1994, pp. 1051–56. Pubmed, doi:10.1016/s0968-0896(00)82054-4.
Journal cover image

Published In

Bioorg Med Chem

DOI

ISSN

0968-0896

Publication Date

October 1994

Volume

2

Issue

10

Start / End Page

1051 / 1056

Location

England

Related Subject Headings

  • Virus Replication
  • T-Lymphocytes
  • Plants, Medicinal
  • Nucleosides
  • Molecular Structure
  • Medicinal & Biomolecular Chemistry
  • HIV Infections
  • HIV Core Protein p24
  • HIV
  • Enzyme-Linked Immunosorbent Assay