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Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography.

Publication ,  Journal Article
Wang, Y; Lu, A; Gil-Flamer, J; Tan, O; Izatt, JA; Huang, D
Published in: The British journal of ophthalmology
May 2009

To measure total retinal blood flow in normal human eyes using Doppler Fourier-domain optical coherence tomography (FD-OCT).10 normal people aged 35 to 69 years were measured for the right eye using Doppler FD-OCT. Double circular scans around the optic nerve heads were used. Four pairs of circular scans that transected all retinal branch vessels were completed in 2 s. Total retinal blood flow was obtained by summing the flows in the branch veins. Measurements from the eight scans were averaged. Veins with diameters >33 microm were taken into account.Total retinal blood flow could be measured in eight of 10 subjects: mean (SD) = 45.6 (3.8) microl/min (range 40.8 to 52.9 microl/min). The coefficient of variation for repeated measurements was 10.5%. Measured vein diameters ranged from 33.3 to 155.4 mum. The averaged flow speed was 19.3 (2.9) mm/s, which did not correlate with vessel diameter. There was no significant difference between flows in the superior and inferior retinal hemispheres.Double circular scanning using Doppler FD-OCT is a rapid and reproducible method to measure total retinal blood flow. These flow values are within the range previously established by laser Doppler flowmetry.

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Published In

The British journal of ophthalmology

DOI

EISSN

1468-2079

ISSN

0007-1161

Publication Date

May 2009

Volume

93

Issue

5

Start / End Page

634 / 637

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Vessels
  • Retinal Vein
  • Reproducibility of Results
  • Regional Blood Flow
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Image Interpretation, Computer-Assisted
  • Humans
 

Citation

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Wang, Y., Lu, A., Gil-Flamer, J., Tan, O., Izatt, J. A., & Huang, D. (2009). Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography. The British Journal of Ophthalmology, 93(5), 634–637. https://doi.org/10.1136/bjo.2008.150276
Wang, Y., A. Lu, J. Gil-Flamer, O. Tan, J. A. Izatt, and D. Huang. “Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography.The British Journal of Ophthalmology 93, no. 5 (May 2009): 634–37. https://doi.org/10.1136/bjo.2008.150276.
Wang Y, Lu A, Gil-Flamer J, Tan O, Izatt JA, Huang D. Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography. The British journal of ophthalmology. 2009 May;93(5):634–7.
Wang, Y., et al. “Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography.The British Journal of Ophthalmology, vol. 93, no. 5, May 2009, pp. 634–37. Epmc, doi:10.1136/bjo.2008.150276.
Wang Y, Lu A, Gil-Flamer J, Tan O, Izatt JA, Huang D. Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography. The British journal of ophthalmology. 2009 May;93(5):634–637.

Published In

The British journal of ophthalmology

DOI

EISSN

1468-2079

ISSN

0007-1161

Publication Date

May 2009

Volume

93

Issue

5

Start / End Page

634 / 637

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Vessels
  • Retinal Vein
  • Reproducibility of Results
  • Regional Blood Flow
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Image Interpretation, Computer-Assisted
  • Humans