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In vivo imaging of human retinal flow dynamics by color Doppler optical coherence tomography.

Publication ,  Journal Article
Yazdanfar, S; Rollins, AM; Izatt, JA
Published in: Archives of ophthalmology (Chicago, Ill. : 1960)
February 2003

Color Doppler optical coherence tomography (CDOCT) combines laser Doppler velocimetry and optical coherence tomography for simultaneous micron-scale resolution cross-sectional imaging of tissue microstructure and blood flow. Recently, CDOCT was adapted to a slitlamp biomicroscope for imaging structure and blood flow in the human retina.To demonstrate feasibility of CDOCT for imaging retinal hemodynamics.Enabling CDOCT to measure retinal blood flow pulsatility in humans.Laboratory.Time-resolved flow profiles and images of retinal blood flow dynamics for measurement of pulsatility within retinal vessels.Rapid sequences of images were acquired over selected vessels near the optic nerve head. From these images, retinal blood flow profiles were extracted and synchronized to an external reference obtained with a photoplethysmograph. Each profile was acquired in less than 10 milliseconds.Our results indicate that CDOCT provides laser Doppler information in addition to conventional optical coherence tomography, allowing the observation of blood flow dynamics simultaneous to imaging retinal structure. CDOCT is a promising technology for research and clinical studies of retinal blood flow dynamics.Blood flow dynamics, such as pulsatility and autoregulation, have been shown to change throughout the progression of diabetic retinopathy and glaucoma. Enabling CDOCT to observe retinal dynamics improves its potential as a clinical diagnostic tool.

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Published In

Archives of ophthalmology (Chicago, Ill. : 1960)

DOI

EISSN

1538-3601

ISSN

0003-9950

Publication Date

February 2003

Volume

121

Issue

2

Start / End Page

235 / 239

Related Subject Headings

  • Tomography
  • Retinal Vessels
  • Regional Blood Flow
  • Pulsatile Flow
  • Plethysmography
  • Ophthalmology & Optometry
  • Light
  • Laser-Doppler Flowmetry
  • Interferometry
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Yazdanfar, S., Rollins, A. M., & Izatt, J. A. (2003). In vivo imaging of human retinal flow dynamics by color Doppler optical coherence tomography. Archives of Ophthalmology (Chicago, Ill. : 1960), 121(2), 235–239. https://doi.org/10.1001/archopht.121.2.235
Yazdanfar, Siavash, Andrew M. Rollins, and Joseph A. Izatt. “In vivo imaging of human retinal flow dynamics by color Doppler optical coherence tomography.Archives of Ophthalmology (Chicago, Ill. : 1960) 121, no. 2 (February 2003): 235–39. https://doi.org/10.1001/archopht.121.2.235.
Yazdanfar S, Rollins AM, Izatt JA. In vivo imaging of human retinal flow dynamics by color Doppler optical coherence tomography. Archives of ophthalmology (Chicago, Ill : 1960). 2003 Feb;121(2):235–9.
Yazdanfar, Siavash, et al. “In vivo imaging of human retinal flow dynamics by color Doppler optical coherence tomography.Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 121, no. 2, Feb. 2003, pp. 235–39. Epmc, doi:10.1001/archopht.121.2.235.
Yazdanfar S, Rollins AM, Izatt JA. In vivo imaging of human retinal flow dynamics by color Doppler optical coherence tomography. Archives of ophthalmology (Chicago, Ill : 1960). 2003 Feb;121(2):235–239.

Published In

Archives of ophthalmology (Chicago, Ill. : 1960)

DOI

EISSN

1538-3601

ISSN

0003-9950

Publication Date

February 2003

Volume

121

Issue

2

Start / End Page

235 / 239

Related Subject Headings

  • Tomography
  • Retinal Vessels
  • Regional Blood Flow
  • Pulsatile Flow
  • Plethysmography
  • Ophthalmology & Optometry
  • Light
  • Laser-Doppler Flowmetry
  • Interferometry
  • Humans