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HIV envelope gp120 activates human arterial smooth muscle cells.

Publication ,  Journal Article
Schecter, AD; Berman, AB; Yi, L; Mosoian, A; McManus, CM; Berman, JW; Klotman, ME; Taubman, MB
Published in: Proc Natl Acad Sci U S A
August 28, 2001

There have been increasing reports of acute coronary thrombotic events in patients with HIV. Although these clinical events have been attributed primarily to dyslipidemia associated with protease inhibitor therapy, autopsy studies in children with HIV suggest the presence of an underlying arteriopathy. This study demonstrates that the HIV envelope protein, gp120, activates human arterial smooth muscle cells to express tissue factor, the initiator of the coagulation cascade. The induction of tissue factor by gp120 is mediated by two biologically relevant coreceptors for HIV infection, CXCR4 and CCR5, and is also dependent on the presence of functional CD4. Induction of tissue factor by gp120 requires activation of mitogen-activating protein kinases, activation of protein kinase C, and generation of reactive oxygen species, signaling pathways that have protean effects on smooth muscle cell physiology. The activation of smooth muscle cells by gp120 may play an important role in the vascular, thrombotic, and inflammatory responses to HIV infection.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

August 28, 2001

Volume

98

Issue

18

Start / End Page

10142 / 10147

Location

United States

Related Subject Headings

  • Thromboplastin
  • Recombinant Proteins
  • Receptors, CXCR4
  • Receptors, CCR5
  • Reactive Oxygen Species
  • Protein Kinase C
  • Muscle, Smooth, Vascular
  • Mitogen-Activated Protein Kinases
  • Ligands
  • Humans
 

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Schecter, A. D., Berman, A. B., Yi, L., Mosoian, A., McManus, C. M., Berman, J. W., … Taubman, M. B. (2001). HIV envelope gp120 activates human arterial smooth muscle cells. Proc Natl Acad Sci U S A, 98(18), 10142–10147. https://doi.org/10.1073/pnas.181328798
Schecter, A. D., A. B. Berman, L. Yi, A. Mosoian, C. M. McManus, J. W. Berman, M. E. Klotman, and M. B. Taubman. “HIV envelope gp120 activates human arterial smooth muscle cells.Proc Natl Acad Sci U S A 98, no. 18 (August 28, 2001): 10142–47. https://doi.org/10.1073/pnas.181328798.
Schecter AD, Berman AB, Yi L, Mosoian A, McManus CM, Berman JW, et al. HIV envelope gp120 activates human arterial smooth muscle cells. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10142–7.
Schecter, A. D., et al. “HIV envelope gp120 activates human arterial smooth muscle cells.Proc Natl Acad Sci U S A, vol. 98, no. 18, Aug. 2001, pp. 10142–47. Pubmed, doi:10.1073/pnas.181328798.
Schecter AD, Berman AB, Yi L, Mosoian A, McManus CM, Berman JW, Klotman ME, Taubman MB. HIV envelope gp120 activates human arterial smooth muscle cells. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10142–10147.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

August 28, 2001

Volume

98

Issue

18

Start / End Page

10142 / 10147

Location

United States

Related Subject Headings

  • Thromboplastin
  • Recombinant Proteins
  • Receptors, CXCR4
  • Receptors, CCR5
  • Reactive Oxygen Species
  • Protein Kinase C
  • Muscle, Smooth, Vascular
  • Mitogen-Activated Protein Kinases
  • Ligands
  • Humans