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Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon.

Publication ,  Journal Article
D'Emilia, JC; Mathey-Prevot, B; Jaros, K; Wolf, B; Steele, G; Summerhayes, IC
Published in: Oncogene
February 1991

With the use of viral vectors harboring myc and src oncogenes, we have assessed the potential contribution of these different elements to colonic neoplasia using a transplantation technique resulting in the formation of a heterotopic colon in Wistar Furth rats. While myc alone induced atypia and some dysplasia, src induced focal dysplastic lesions throughout the colon mucosa with evidence of metaplasia. In contrast, lesions induced by myc and src acting cooperatively, were highly dysplastic with evidence of tumor formation after protracted periods. These results indicated the formation of histologically distinct preneoplastic lesions elicited by the action of a single oncogene in colon implants with the production of adenocarcinomas when such oncogenic elements act cooperatively. This model provides an opportunity for studies of the action of different oncogenes, acting singly or in combination, in the multi-step progression to colon tumor formation.

Published In

Oncogene

ISSN

0950-9232

Publication Date

February 1991

Volume

6

Issue

2

Start / End Page

303 / 309

Location

England

Related Subject Headings

  • Retroviridae
  • Rats, Inbred Strains
  • Rats
  • Precancerous Conditions
  • Phenotype
  • Oncology & Carcinogenesis
  • Genes, src
  • Genes, myc
  • Colonic Neoplasms
  • Colon
 

Citation

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D’Emilia, J. C., Mathey-Prevot, B., Jaros, K., Wolf, B., Steele, G., & Summerhayes, I. C. (1991). Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon. Oncogene, 6(2), 303–309.
D’Emilia, J. C., B. Mathey-Prevot, K. Jaros, B. Wolf, G. Steele, and I. C. Summerhayes. “Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon.Oncogene 6, no. 2 (February 1991): 303–9.
D’Emilia JC, Mathey-Prevot B, Jaros K, Wolf B, Steele G, Summerhayes IC. Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon. Oncogene. 1991 Feb;6(2):303–9.
D’Emilia, J. C., et al. “Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon.Oncogene, vol. 6, no. 2, Feb. 1991, pp. 303–09.
D’Emilia JC, Mathey-Prevot B, Jaros K, Wolf B, Steele G, Summerhayes IC. Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon. Oncogene. 1991 Feb;6(2):303–309.

Published In

Oncogene

ISSN

0950-9232

Publication Date

February 1991

Volume

6

Issue

2

Start / End Page

303 / 309

Location

England

Related Subject Headings

  • Retroviridae
  • Rats, Inbred Strains
  • Rats
  • Precancerous Conditions
  • Phenotype
  • Oncology & Carcinogenesis
  • Genes, src
  • Genes, myc
  • Colonic Neoplasms
  • Colon