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A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice.

Publication ,  Journal Article
Nussenzweig, MC; Schmidt, EV; Shaw, AC; Sinn, E; Campos-Torres, J; Mathey-Prevot, B; Pattengale, PK; Leder, P
Published in: Nature
December 1, 1988

Transgenic mice carrying an immunoglobulin enhancer-driven c-myc oncogene develop rapid-onset pre-B cell lymphomas. The incidence of these malignancies is greatly reduced when an additional transgene encoding the membrane-bound form (but not the secreted form) of human Ig mu is bred into the susceptible strain. This suppressive effect correlates with a subtle alteration in B-cell development induced by the immunoglobulin transgene.

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Published In

Nature

DOI

ISSN

0028-0836

Publication Date

December 1, 1988

Volume

336

Issue

6198

Start / End Page

446 / 450

Location

England

Related Subject Headings

  • RNA, Messenger
  • Proto-Oncogenes
  • Proto-Oncogene Proteins c-myc
  • Proto-Oncogene Proteins
  • Phenotype
  • Mice, Transgenic
  • Mice
  • Lymphoma
  • Immunoglobulin mu-Chains
  • Humans
 

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Nussenzweig, M. C., Schmidt, E. V., Shaw, A. C., Sinn, E., Campos-Torres, J., Mathey-Prevot, B., … Leder, P. (1988). A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice. Nature, 336(6198), 446–450. https://doi.org/10.1038/336446a0
Nussenzweig, M. C., E. V. Schmidt, A. C. Shaw, E. Sinn, J. Campos-Torres, B. Mathey-Prevot, P. K. Pattengale, and P. Leder. “A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice.Nature 336, no. 6198 (December 1, 1988): 446–50. https://doi.org/10.1038/336446a0.
Nussenzweig MC, Schmidt EV, Shaw AC, Sinn E, Campos-Torres J, Mathey-Prevot B, et al. A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice. Nature. 1988 Dec 1;336(6198):446–50.
Nussenzweig, M. C., et al. “A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice.Nature, vol. 336, no. 6198, Dec. 1988, pp. 446–50. Pubmed, doi:10.1038/336446a0.
Nussenzweig MC, Schmidt EV, Shaw AC, Sinn E, Campos-Torres J, Mathey-Prevot B, Pattengale PK, Leder P. A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice. Nature. 1988 Dec 1;336(6198):446–450.
Journal cover image

Published In

Nature

DOI

ISSN

0028-0836

Publication Date

December 1, 1988

Volume

336

Issue

6198

Start / End Page

446 / 450

Location

England

Related Subject Headings

  • RNA, Messenger
  • Proto-Oncogenes
  • Proto-Oncogene Proteins c-myc
  • Proto-Oncogene Proteins
  • Phenotype
  • Mice, Transgenic
  • Mice
  • Lymphoma
  • Immunoglobulin mu-Chains
  • Humans