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[Endogenous inhibitors of the specific binding of benzodiazepines in the cerebral cortex].

Publication ,  Journal Article
Kladnitskiĭ, AV; Mukhin, AG
Published in: Zh Nevropatol Psikhiatr Im S S Korsakova
1988

The nature of inhibitors of [3H]-diazepam (D) specific binding (SB) was studied in 2 fractions of acidic extract from bovine brain cortex. Preparative high-performance liquid chromatography (HPLC), mass spectrometry, UV and IR techniques identified hypoxanthine and inosine as inhibitors of SB D. These substances may participate in the neuronal activity control which is in part mediated by the benzodiazepine receptors.

Published In

Zh Nevropatol Psikhiatr Im S S Korsakova

ISSN

0044-4588

Publication Date

1988

Volume

88

Issue

12

Start / End Page

98 / 103

Location

Russia (Federation)

Related Subject Headings

  • Spectrophotometry, Ultraviolet
  • Spectrophotometry, Infrared
  • Receptors, GABA-A
  • Radioligand Assay
  • Mass Spectrometry
  • Male
  • Inosine
  • Hypoxanthines
  • Hypoxanthine
  • Diazepam
 

Citation

APA
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ICMJE
MLA
NLM
Kladnitskiĭ, A. V., & Mukhin, A. G. (1988). [Endogenous inhibitors of the specific binding of benzodiazepines in the cerebral cortex]. Zh Nevropatol Psikhiatr Im S S Korsakova, 88(12), 98–103.
Kladnitskiĭ, A. V., and A. G. Mukhin. “[Endogenous inhibitors of the specific binding of benzodiazepines in the cerebral cortex].Zh Nevropatol Psikhiatr Im S S Korsakova 88, no. 12 (1988): 98–103.
Kladnitskiĭ AV, Mukhin AG. [Endogenous inhibitors of the specific binding of benzodiazepines in the cerebral cortex]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(12):98–103.
Kladnitskiĭ, A. V., and A. G. Mukhin. “[Endogenous inhibitors of the specific binding of benzodiazepines in the cerebral cortex].Zh Nevropatol Psikhiatr Im S S Korsakova, vol. 88, no. 12, 1988, pp. 98–103.
Kladnitskiĭ AV, Mukhin AG. [Endogenous inhibitors of the specific binding of benzodiazepines in the cerebral cortex]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(12):98–103.

Published In

Zh Nevropatol Psikhiatr Im S S Korsakova

ISSN

0044-4588

Publication Date

1988

Volume

88

Issue

12

Start / End Page

98 / 103

Location

Russia (Federation)

Related Subject Headings

  • Spectrophotometry, Ultraviolet
  • Spectrophotometry, Infrared
  • Receptors, GABA-A
  • Radioligand Assay
  • Mass Spectrometry
  • Male
  • Inosine
  • Hypoxanthines
  • Hypoxanthine
  • Diazepam